P-selectin antagonism reduces thrombus formation in humans

R Chelliah; A J Lucking; L Tattersall; S Daga; N J Beresford-Cleary; K Cortas; K A A Fox; G Z Feuerstein; T M Connolly; D E Newby

doi:10.1111/j.1538-7836.2009.03587.x

P-selectin antagonism reduces thrombus formation in humans

R Chelliah, A J Lucking, L Tattersall, S Daga, N J Beresford-Cleary, K Cortas, K A A Fox, G Z Feuerstein, T M Connolly, D E Newby

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.

Original language	English
Pages (from-to)	1915-9
Number of pages	5
Journal	Journal of Thrombosis and Haemostasis
Volume	7
Issue number	11
DOIs	https://doi.org/10.1111/j.1538-7836.2009.03587.x
Publication status	Published - Nov 2009

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title = "P-selectin antagonism reduces thrombus formation in humans",

abstract = "Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.",

author = "R Chelliah and Lucking, {A J} and L Tattersall and S Daga and Beresford-Cleary, {N J} and K Cortas and Fox, {K A A} and Feuerstein, {G Z} and Connolly, {T M} and Newby, {D E}",

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T1 - P-selectin antagonism reduces thrombus formation in humans

AU - Chelliah, R

AU - Lucking, A J

AU - Tattersall, L

AU - Daga, S

AU - Beresford-Cleary, N J

AU - Cortas, K

AU - Fox, K A A

AU - Feuerstein, G Z

AU - Connolly, T M

AU - Newby, D E

PY - 2009/11

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N2 - Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.

AB - Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.

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U2 - 10.1111/j.1538-7836.2009.03587.x

DO - 10.1111/j.1538-7836.2009.03587.x

M3 - Article

C2 - 19691482

SN - 1538-7933

VL - 7

SP - 1915

EP - 1919

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 11

ER -

P-selectin antagonism reduces thrombus formation in humans

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