p21: structure and functions associated with cyclin-CDK binding

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The cyclin dependent kinase inhibitor, p21, is a multifunctional protein involved in coordinating the cellular response to negative growth signals. Induced by cellular damage under the transcriptional control of the p53 tumour suppressor protein, p21 interfaces with a number of cellular proteins involved in growth control. Although p21 has a diverse range of activities, from assembly factor to transcriptional modulator, its ability to interact with and regulate the activity of the cyclin dependent protein kinases is paramount to many of these functions.
Original languageEnglish
Pages (from-to)125-34
Number of pages10
JournalProgress in cell cycle research
Publication statusPublished - 1997

Keywords / Materials (for Non-textual outputs)

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Cell Cycle
  • Cell Division
  • Conserved Sequence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinases
  • Cyclins
  • Enzyme Inhibitors
  • Humans
  • Macromolecular Substances
  • Neoplasms


Dive into the research topics of 'p21: structure and functions associated with cyclin-CDK binding'. Together they form a unique fingerprint.

Cite this