Flavocytochrome P450 BM3 is a bacterial P450 system in which a fatty acid hydroxylase P450 is fused to a mammalian-like diflavin NADPH-P450 reductase in a single polypeptide. The enzyme is soluble (unlike mammalian P450 redox systems) and its fusion arrangement affords it the highest catalytic activity of any P450 mono-oxygenase. This article discusses the fundamental properties of P450 BM3 and how progress with this model P450 has affected our comprehension of P450 systems in general.
|Number of pages||8|
|Journal||Trends in biochemical sciences|
|Publication status||Published - May 2002|
- CYTOCHROME P450
- CATALYTIC CYCLE
- DOMAIN MOVEMENT
- P-450 BM3