p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells

Qiyi Yi, Xiaoyu Zhao, Yun Huang, Tieliang Ma, Yingyin Zhang, Heli Hou, Howard J Cooke, Da-Qing Yang, Mian Wu, Qinghua Shi

Research output: Contribution to journalArticlepeer-review

Abstract

p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy.
Original languageEnglish
Pages (from-to)e27304
JournalPLoS ONE
Volume6
Issue number11
DOIs
Publication statusPublished - 2011

Keywords

  • Aneuploidy
  • Animals
  • Cell Cycle
  • Cells, Cultured
  • Centrosome
  • Embryo, Mammalian
  • Fibroblasts
  • Fluorescent Antibody Technique
  • Genomic Instability
  • Humans
  • Image Processing, Computer-Assisted
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mitosis
  • Mitotic Spindle Apparatus
  • Tetraploidy
  • Tumor Suppressor Protein p53
  • rhoA GTP-Binding Protein

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