p75NTR: an enhancer of fenretinide toxicity in neuroblastoma

Veena Ganeshan; John Ashton; Nina F Schor

doi:10.1007/s00280-013-2071-7

p75NTR: an enhancer of fenretinide toxicity in neuroblastoma

Veena Ganeshan, John Ashton, Nina F Schor

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Abstract

Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would influence the effects of the redox-active chemotherapeutic drug fenretinide on neuroblastoma cells.

Original language	English
Pages (from-to)	777-87
Number of pages	11
Journal	Cancer chemotherapy and pharmacology
Volume	71
Issue number	3
DOIs	https://doi.org/10.1007/s00280-013-2071-7
Publication status	Published - Mar 2013

Keywords

Antineoplastic Agents
Antioxidants
Apoptosis
Blotting, Western
Brain Neoplasms
Cell Line, Tumor
Cell Membrane
Cell Survival
Electron Transport
Fenretinide
Gene Expression Regulation, Neoplastic
Humans
Indicators and Reagents
Mitochondria
Nerve Tissue Proteins
Neuroblastoma
Oxidation-Reduction
RNA, Small Interfering
Reactive Oxygen Species
Receptors, Nerve Growth Factor
Signal Transduction

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10.1007/s00280-013-2071-7

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581726/

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Cite this

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title = "p75NTR: an enhancer of fenretinide toxicity in neuroblastoma",

abstract = "Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ({"}S-type{"}) morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would influence the effects of the redox-active chemotherapeutic drug fenretinide on neuroblastoma cells.",

keywords = "Antineoplastic Agents, Antioxidants, Apoptosis, Blotting, Western, Brain Neoplasms, Cell Line, Tumor, Cell Membrane, Cell Survival, Electron Transport, Fenretinide, Gene Expression Regulation, Neoplastic, Humans, Indicators and Reagents, Mitochondria, Nerve Tissue Proteins, Neuroblastoma, Oxidation-Reduction, RNA, Small Interfering, Reactive Oxygen Species, Receptors, Nerve Growth Factor, Signal Transduction",

author = "Veena Ganeshan and John Ashton and Schor, {Nina F}",

year = "2013",

month = mar,

doi = "10.1007/s00280-013-2071-7",

language = "English",

volume = "71",

pages = "777--87",

journal = "Cancer chemotherapy and pharmacology",

issn = "0344-5704",

publisher = "Springer Verlag",

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TY - JOUR

T1 - p75NTR

T2 - an enhancer of fenretinide toxicity in neuroblastoma

AU - Ganeshan, Veena

AU - Ashton, John

AU - Schor, Nina F

PY - 2013/3

Y1 - 2013/3

N2 - Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would influence the effects of the redox-active chemotherapeutic drug fenretinide on neuroblastoma cells.

AB - Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would influence the effects of the redox-active chemotherapeutic drug fenretinide on neuroblastoma cells.

KW - Antineoplastic Agents

KW - Antioxidants

KW - Apoptosis

KW - Blotting, Western

KW - Brain Neoplasms

KW - Cell Line, Tumor

KW - Cell Membrane

KW - Cell Survival

KW - Electron Transport

KW - Fenretinide

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Indicators and Reagents

KW - Mitochondria

KW - Nerve Tissue Proteins

KW - Neuroblastoma

KW - Oxidation-Reduction

KW - RNA, Small Interfering

KW - Reactive Oxygen Species

KW - Receptors, Nerve Growth Factor

KW - Signal Transduction

U2 - 10.1007/s00280-013-2071-7

DO - 10.1007/s00280-013-2071-7

M3 - Article

C2 - 23314735

VL - 71

SP - 777

EP - 787

JO - Cancer chemotherapy and pharmacology

JF - Cancer chemotherapy and pharmacology

SN - 0344-5704

IS - 3

ER -

p75NTR: an enhancer of fenretinide toxicity in neuroblastoma

Abstract

Keywords

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