p75NTR: an enhancer of fenretinide toxicity in neuroblastoma

Veena Ganeshan, John Ashton, Nina F Schor

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would influence the effects of the redox-active chemotherapeutic drug fenretinide on neuroblastoma cells.
Original languageEnglish
Pages (from-to)777-87
Number of pages11
JournalCancer chemotherapy and pharmacology
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Antineoplastic Agents
  • Antioxidants
  • Apoptosis
  • Blotting, Western
  • Brain Neoplasms
  • Cell Line, Tumor
  • Cell Membrane
  • Cell Survival
  • Electron Transport
  • Fenretinide
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Indicators and Reagents
  • Mitochondria
  • Nerve Tissue Proteins
  • Neuroblastoma
  • Oxidation-Reduction
  • RNA, Small Interfering
  • Reactive Oxygen Species
  • Receptors, Nerve Growth Factor
  • Signal Transduction

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