Palladium in biological media: Can the synthetic chemist's most versatile transition metal become a powerful biological tool?

Richard C. Brewster, Eva Klemencic, Amanda G. Jarvis

Research output: Contribution to journalArticlepeer-review

Abstract

Palladium catalysed reactions are ubiquitous in synthetic organic chemistry in both organic solvents and aqueous buffers. The broad reactivity of palladium catalysis has drawn interest as a means to conduct orthogonal transformations in biological settings. Successful examples have been shown for protein modification, in vivo drug decaging and as palladium-protein biohybrid catalysts for selective catalysis. Biological media represents a challenging environment for palladium chemistry due to the presence of a multitude of chelators, catalyst poisons and a requirement for milder reaction conditions e.g. lower temperatures. This review looks to identify successful examples of palladium-catalysed reactions in the presence of proteins or cells and analyse solutions to help to overcome the challenges of working in biological systems.
Original languageEnglish
Article number111317
JournalJournal of Inorganic Biochemistry
Volume215
Issue number12
Early online date1 Dec 2020
DOIs
Publication statusPublished - 1 Feb 2021

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