Palladium-mediated 11C-carbonylations using aryl halides and cyanamide

P. Nordeman, S. Y. Chow, A. F. Odell, G. Antoni, L. R. Odell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A robust and high-yielding radiochemical synthesis of 11C-N-cyanobenzamides using a palladium-mediated aminocarbonylation with 11C-CO, aryl halides and cyanamide is described. The bidentate ligand 1,1′-bis(diphenylphosphino)ferrocene provided 11C-N-cyanobenzamides from aryl-iodides, bromides, triflates and even chlorides in 28-79% radiochemical yield after semi-preparative HPLC. To further highlight the utility of this method, novel 11C-N-cyanobenzamide analogs of flufenamic acid, meflanamic acid, dazoxiben and tamibarotene were synthesized in 34-71% radiochemical yields.

Original languageEnglish
Pages (from-to)4875-4881
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number22
Early online date12 May 2017
DOIs
Publication statusE-pub ahead of print - 12 May 2017

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