Palladium nanoparticles from desulfovibrio alaskensis G20 catalyze biocompatible sonogashira and biohydrogenation cascades

Yuta Era, Jonathan A. Dennis, Louise E. Horsfall, Stephen Wallace

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Transition-metal nanoparticles produced by living bacteria are emerging as novel catalysts for sustainable synthesis. However, the scope of their catalytic activity and their ability to be integrated within metabolic pathways for the bioproduction of non-natural small molecules has been underexplored. Herein we report that Pd nanoparticles synthesized by the sulfate-reducing bacterium Desulfovibrio alaskensis G20 (DaPdNPs) catalyze the Sonogashira coupling of phenyl acetylenes and aryl iodides, and the subsequent one-pot hydrogenation to bibenzyl derivatives using hydrogen gas generated from d-glucose by engineered Escherichia coli DD-2. The formal hydroarylation reaction is biocompatible, occurs in aqueous media at ambient temperature, and affords products in 70–99% overall yield. This is the first reported microbial nanoparticle to catalyze the Sonogashira reaction and the first demonstration that these biogenic catalysts can be interfaced with the products of engineered metabolism for small molecule synthesis.
Original languageEnglish
Pages (from-to)2446-2452
JournalJACS Au
Volume2
Issue number11
Early online date19 Oct 2022
DOIs
Publication statusPublished - 28 Nov 2022

Keywords / Materials (for Non-textual outputs)

  • biocompatible chemistry
  • nanopatricles
  • cascade
  • microorganisms
  • green chemistry

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