Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models

Jian-Dong Li*, Ann Hermansson, Allen F. Ryan, Lauren O. Bakaletz, Steve D. Brown, Michael T. Cheeseman, Steven K. Juhn, Timothy T. K. Jung, David J. Lim, Jae Hyang Lim, Jizhen Lin, Sung-Kyun Moon, J. Christopher Post

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Background. Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.

Objective. To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas.

Data Sources and Review Methods. A structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM.

Results. Over the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM.

Conclusions and Implications for Practice. Our understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications.

Original languageEnglish
Pages (from-to)E52-E63
Number of pages12
JournalOtolaryngology - Head and Neck Surgery
Volume148
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords / Materials (for Non-textual outputs)

  • inflammation
  • chemokine
  • BETA PATHWAY
  • SENSORINEURAL HEARING-LOSS
  • biochemistry
  • tissue remodeling
  • HUMAN MIDDLE-EAR
  • otitis media
  • molecular biology
  • RECEPTORS 2
  • SIGNALING PATHWAY
  • NONTYPABLE HAEMOPHILUS-INFLUENZAE
  • NF-KAPPA-B
  • cell signaling
  • cytokine
  • C3H/HEJ MICE
  • STREPTOCOCCUS-PNEUMONIAE
  • innate immunity
  • MUC5AC MUCIN

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