ParAlleL: A Novel Population-Based Approach to Biological Logic Gates

Felipe A Millacura, Brendan Largey, Christopher E French

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In vivo logic gates have proven difficult to combine into larger devices. Our cell-based logic system, ParAlleL, decomposes a large circuit into a collection of small subcircuits working in parallel, each subcircuit responding to a different combination of inputs. A final global output is then generated by a combination of the responses. Using ParAlleL, for the first time a completely functional 3-bit full adder and full subtractor were generated using Escherichia coli cells, as well as a calculator-style display that shows a numeric result, from 0 to 7, when the proper 3 bit binary inputs are introduced into the system. ParAlleL demonstrates the use of a parallel approach for the design of cell-based logic gates that facilitates the generation and analysis of complex processes, without the need for complex genetic engineering.

Original languageEnglish
Article number46
Number of pages6
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 21 Mar 2019

Keywords / Materials (for Non-textual outputs)

  • 3-bits
  • Escherichia coli
  • calculator-like display
  • full adder
  • full subtractor
  • parallel approach


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