Projects per year
Abstract / Description of output
In vivo logic gates have proven difficult to combine into larger devices. Our cell-based logic system, ParAlleL, decomposes a large circuit into a collection of small subcircuits working in parallel, each subcircuit responding to a different combination of inputs. A final global output is then generated by a combination of the responses. Using ParAlleL, for the first time a completely functional 3-bit full adder and full subtractor were generated using Escherichia coli cells, as well as a calculator-style display that shows a numeric result, from 0 to 7, when the proper 3 bit binary inputs are introduced into the system. ParAlleL demonstrates the use of a parallel approach for the design of cell-based logic gates that facilitates the generation and analysis of complex processes, without the need for complex genetic engineering.
Keywords / Materials (for Non-textual outputs)
- Escherichia coli
- calculator-like display
- full adder
- full subtractor
- parallel approach
FingerprintDive into the research topics of 'ParAlleL: A Novel Population-Based Approach to Biological Logic Gates'. Together they form a unique fingerprint.
- 1 Finished
RCUK-CONICYT: Utilising functional genomic variation for improved disease resistance in Chilean salmon aquaculture
Houston, R. & Hickey, J.
1/02/16 → 30/11/18