Projects per year
Abstract
In vivo logic gates have proven difficult to combine into larger devices. Our cell-based logic system, ParAlleL, decomposes a large circuit into a collection of small subcircuits working in parallel, each subcircuit responding to a different combination of inputs. A final global output is then generated by a combination of the responses. Using ParAlleL, for the first time a completely functional 3-bit full adder and full subtractor were generated using Escherichia coli cells, as well as a calculator-style display that shows a numeric result, from 0 to 7, when the proper 3 bit binary inputs are introduced into the system. ParAlleL demonstrates the use of a parallel approach for the design of cell-based logic gates that facilitates the generation and analysis of complex processes, without the need for complex genetic engineering.
Original language | English |
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Article number | 46 |
Number of pages | 6 |
Journal | Frontiers in Bioengineering and Biotechnology |
Volume | 7 |
DOIs | |
Publication status | Published - 21 Mar 2019 |
Keywords / Materials (for Non-textual outputs)
- 3-bits
- Escherichia coli
- calculator-like display
- full adder
- full subtractor
- parallel approach
Fingerprint
Dive into the research topics of 'ParAlleL: A Novel Population-Based Approach to Biological Logic Gates'. Together they form a unique fingerprint.Projects
- 1 Finished
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RCUK-CONICYT: Utilising functional genomic variation for improved disease resistance in Chilean salmon aquaculture
Houston, R. & Hickey, J.
1/02/16 → 30/11/18
Project: Research
Datasets
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ParAlleL plasmid sequences in SBOL, GENBANK and FASTA format
French, C. (Creator) & Aguilera millacura, F. (Creator), Edinburgh DataShare, 14 Feb 2019
DOI: 10.7488/ds/2497, https://www.frontiersin.org/articles/10.3389/fbioe.2019.00046/abstract
Dataset
Profiles
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Chris French
- School of Biological Sciences - Personal Chair of Microbial Biotechnology
- Centre for Engineering Biology
Person: Academic: Research Active