Paraneoplastic leukocytosis in a dog following liposarcoma resection

Simone Cutler*, Laura Blackwood, KM Pratschke, Maciej Parys, Adrian Philbey, Myrto Spyropoulou , Daria Starybrat, Craig Breheny

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A 10-year-old, female, neutered cocker spaniel presented for surgical debulking of an axillary and cranial thoracic wall liposarcoma. Pre-surgical blood analysis demonstrated anaemia (packed cell volume 17%), leukocytosis (white blood cell count 43.95 × 10 9/L) and thrombocytopenia (15 × 10 9/L), with platelet loss secondary to chronic intra-lesional haemorrhage or immune-mediated destruction, and concomitant Staphylococcus pseudintermedius urinary tract infection. A blood transfusion and antibiotics were administered before surgery. Within 48 hours after surgery, an extreme leukocytosis (white blood cell count 170 × 10 9/L), involving a severe left shift neutrophilia (95 × 10 9/L) was observed; this resolved within 10 days. Serum granulocyte-colony stimulating factor levels were similar to controls. The extreme leukocytosis was suspected to be related to a paraneoplastic leukaemoid reaction combined with an expected postoperative mild leukocytosis. Further investigation into the pathophysiology underlying similar cases is required. One month after surgery, all haematological abnormalities had normalised, and metronomic chemotherapy with chlorambucil commenced.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalVet Record Case Reports
Early online date20 Mar 2024
DOIs
Publication statusE-pub ahead of print - 20 Mar 2024

Keywords / Materials (for Non-textual outputs)

  • dogs
  • haematology
  • oncology

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