Projects per year
Abstract
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-influenced CpGs. The combined results provide strong evidence for previously unidentified POE-influenced CpGs at 171 independent loci. Methylation variation at 14 of the POE-influenced CpGs is associated with multiple metabolic traits. A phenome-wide association analysis using the POE mQTL SNPs identifies a previously unidentified imprinted locus associated with waist circumference. These results provide a high resolution population-level map for POE on DNA methylation sites, their local and distant regulators and potential consequences for complex traits.
Original language | English |
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Article number | 1383 |
Number of pages | 13 |
Journal | Nature Communications |
Volume | 10 |
DOIs | |
Publication status | Published - 27 Mar 2019 |
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Dive into the research topics of 'Parent of origin genetic effects on methylation in humans are common and influence complex trait variation'. Together they form a unique fingerprint.Projects
- 2 Finished
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Stratifying Resilience and Depression Longitudinally
McIntosh, A., Deary, I., Evans, K., Haley, C. & Porteous, D.
1/01/15 → 30/06/21
Project: Research
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RA2662 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Porteous, D.
1/09/13 → 31/08/19
Project: Research
Research output
- 1 Article
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Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J., Evans, K. L., & 3 others , 1 May 2019, In: Nature Communications. 10, 1, p. 2069Research output: Contribution to journal › Article › peer-review
Open AccessFile
Profiles
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Chris Haley
- Deanery of Molecular, Genetic and Population Health Sciences - Visitor: Default Visitor
Person: Affiliated Independent Researcher
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Andrew McIntosh
- Deanery of Clinical Sciences - Chair of Biological Psychiatry
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
Person: Academic: Research Active