Parkinsonian Tremor Detection from Subthalamic Nucleus Local Field Potentials for Closed-Loop Deep Brain Stimulation

Syed A Shah, Gerd Tinkhauser, Chiung Chu Chen, Simon Little, Peter Brown

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deep Brain Stimulation (DBS) is a widely used therapy to ameliorate symptoms experienced by patients with Parkinson's Disease (PD). Conventional DBS is continuously ON even though PD symptoms fluctuate over time leading to undesirable side-effects and high energy requirements. This study investigates the use of a Iogistic regression-based classifier to identify periods when PD patients have rest tremor exploiting Local Field Potentials (LFPs) recorded with DBS electrodes implanted in the Subthalamic Nucleus in 7 PD patients (8 hemispheres). Analyzing 36.1 minutes of data with a 512 milliseconds non-overlapping window, the classification accuracy was well above chance-level for all patients, with Area Under the Curve (AUC) ranging from 0.67 to 0.93. The features with the most discriminative ability were, in descending order, power in the 31-45 Hz, 5-7 Hz, 21-30 Hz, 46-55 Hz, and 56-95 Hz frequency bands. These results suggest that using a machine learning-based classifier, such as the one proposed in this study, can form the basis for on-demand DBS therapy for PD tremor, with the potential to reduce side-effects and lower battery consumption.

Original languageEnglish
Title of host publication2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages2320-2324
Number of pages5
Volume2018
DOIs
Publication statusPublished - 29 Oct 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Honolulu, United States
Duration: 18 Jul 201821 Jul 2018
https://embc.embs.org/2018/

Publication series

NameConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISSN (Print)1557-170X

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2018
Country/TerritoryUnited States
CityHonolulu
Period18/07/1821/07/18
Internet address

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