Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level

J Mackay, P A Elder, D J Porteous, C M Steel, R A Hawkins, J J Going, U Chetty

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-ras allele correlates with paucity of oestrogen receptor protein and with increased tumour size at presentation, but is not associated with microscopic evidence of lymph node invasion. The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11.
Original languageEnglish
Pages (from-to)710-4
Number of pages5
JournalBritish Journal of Cancer
Volume58
Issue number6
Publication statusPublished - 1988

Keywords / Materials (for Non-textual outputs)

  • Alleles
  • Breast Neoplasms
  • Chromosome Deletion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Female
  • Genes, ras
  • Humans
  • Lymphatic Metastasis
  • Receptors, Estrogen

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