Parts list for a microtubule depolymerising kinesin

Claire T Friel, Julie P Welburn

Research output: Contribution to journalReview articlepeer-review

Abstract

The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways by these motors allowing them to carry out a variety of cellular functions. The Kinesin-13 family is a group of specialist microtubule depolymerising motors. Members of this family use their microtubule destabilising activity to regulate processes such as chromosome segregation, maintenance of cilia and neuronal development. Here, we describe the current understanding of the structure of this family of kinesins and the role different parts of these proteins play in their microtubule depolymerisation activity and in the wider function of this family of kinesins.

Original languageEnglish
Number of pages8
JournalBiochemical Society Transactions
Early online date22 Nov 2018
DOIs
Publication statusE-pub ahead of print - 22 Nov 2018

Keywords

  • cytoskeleton
  • depolymerising
  • kinesin-13
  • kinesins
  • microtubule
  • molecular motors

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