Parvovirus 4 Infection and Clinical Outcome in High-Risk Populations

The Swiss HIV Cohort Study, R. Simmons, C. Sharp, C. P. McClure, J. Rohrbach, H. Kovari, E. Frangou, P. Simmonds, W. Irving, A. Rauch, P. Bowness, P. Klenerman

Research output: Contribution to journalArticlepeer-review


Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV-and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.
Original languageEnglish
Pages (from-to)1816-1820
Number of pages5
JournalThe Journal of Infectious Diseases
Issue number12
Publication statusPublished - 2012

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