Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis

Benito Gonzalez, Carmen Larrañaga, Oscar León, Patricia Díaz, Marta Miranda, Marcelo Barría, Aldo Gaggero

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To determine the prevalence of human parvovirus B19 infection in patients with juvenile idiopathic arthritis (JIA) by detection of specific IgM, IgG, and viral DNA.

METHODS: Serum samples of 50 patients with diagnosis of JIA and 39 healthy controls were analyzed by ELISA to detect IgG and IgM anti-B19-specific antibodies. The parvovirus B19 genome was detected by nested polymerase chain reaction (PCR). The average age of the patients was 9.6 years (2-14 yrs); 30 were female (60%) and 20 male (40%). The definitive diagnoses of these patients corresponded to 19 systemic forms (38%), 11 to the oligoarticular variety (22%) and 20 to the polyarticular (40%). The average age of the control group was 7.8 years (2-16 yrs); the distribution by sex was 25 females (64%) and 14 males (36%).

RESULTS: IgM against parvovirus B19 was detected in 20% of the cases (10 patients) and B19 DNA genome by PCR in 48% (24 patients); in 10% of the cases (5 patients), both markers were detected. IgG was found in 32% (16 patients). In the control group neither IgM nor the viral genome was detected. However, 43.5% of the controls (17/39) had IgG against parvovirus B19, indicating past infection by the virus.

CONCLUSION: Our study confirms recent observations regarding a high prevalence of viral DNA in JIA patients and a possible role of this viral infection in JIA pathogenesis.

Original languageEnglish
Pages (from-to)1336-40
Number of pages5
JournalThe Journal of rheumatology
Volume34
Issue number6
Publication statusPublished - Jun 2007

Keywords

  • Adolescent
  • Antibodies, Viral
  • Arthritis, Juvenile
  • Case-Control Studies
  • Child
  • Child, Preschool
  • DNA, Viral
  • Female
  • Humans
  • Immunoglobulin G
  • Immunoglobulin M
  • Infant
  • Male
  • Parvoviridae Infections
  • Parvovirus B19, Human
  • Prevalence

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