PASAT performance and the pattern of uptake of Tc-99m-exametazime in brain estimated with single photon emission tomography

I J  Deary; K P  Ebmeier; K M  MacLeod; N  Dougall; D A  Hepburn; B M  Frier; G M  Goodwiin

PASAT performance and the pattern of uptake of Tc-99m-exametazime in brain estimated with single photon emission tomography

I J Deary, K P Ebmeier, K M MacLeod, N Dougall, D A Hepburn, B M Frier, G M Goodwiin

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of the paced auditory serial addition test (PASAT) on the regional uptake of Tc-99m-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the performance of the PASAT task using split-dose injection of tracer. When resting and activation scans were compared there were significant decreases in tracer uptake in the right anterior cingulate and left posterior cingulate areas during PASAT activation. The findings are compared with previous studies which had implicated the anterior cingulate area in the mechanisms of attention in humans and other animals. The potentially confounding role of anxiety during attentional tasks is discussed.

Original language	English
Pages (from-to)	118
Number of pages	18
Journal	Biological Psychology
Volume	38
Issue number	1
Publication status	Published - Sept 1994

Keywords / Materials (for Non-textual outputs)

PASAT
SINGLE PHOTON EMISSION TOMOGRAPHY
CINGULATE CORTEX
ATTENTION
CEREBRAL BLOOD-FLOW
RECURRENT SEVERE HYPOGLYCEMIA
ALZHEIMER-TYPE DEMENTIA
COMPUTERIZED-TOMOGRAPHY
MAJOR DEPRESSION
DISEASE
SPECT
ANTERIOR
DISORDER

Cite this

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title = "PASAT performance and the pattern of uptake of Tc-99m-exametazime in brain estimated with single photon emission tomography",

abstract = "The effect of the paced auditory serial addition test (PASAT) on the regional uptake of Tc-99m-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the performance of the PASAT task using split-dose injection of tracer. When resting and activation scans were compared there were significant decreases in tracer uptake in the right anterior cingulate and left posterior cingulate areas during PASAT activation. The findings are compared with previous studies which had implicated the anterior cingulate area in the mechanisms of attention in humans and other animals. The potentially confounding role of anxiety during attentional tasks is discussed.",

keywords = "PASAT, SINGLE PHOTON EMISSION TOMOGRAPHY, CINGULATE CORTEX, ATTENTION, CEREBRAL BLOOD-FLOW, RECURRENT SEVERE HYPOGLYCEMIA, ALZHEIMER-TYPE DEMENTIA, COMPUTERIZED-TOMOGRAPHY, MAJOR DEPRESSION, DISEASE, SPECT, ANTERIOR, DISORDER",

author = "Deary, {I J} and Ebmeier, {K P} and MacLeod, {K M} and N Dougall and Hepburn, {D A} and Frier, {B M} and Goodwiin, {G M}",

year = "1994",

month = sep,

language = "English",

volume = "38",

pages = "118",

journal = "Biological Psychology",

issn = "0301-0511",

publisher = "Elsevier",

number = "1",

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TY - JOUR

T1 - PASAT performance and the pattern of uptake of Tc-99m-exametazime in brain estimated with single photon emission tomography

AU - Deary, I J

AU - Ebmeier, K P

AU - MacLeod, K M

AU - Dougall, N

AU - Hepburn, D A

AU - Frier, B M

AU - Goodwiin, G M

PY - 1994/9

Y1 - 1994/9

N2 - The effect of the paced auditory serial addition test (PASAT) on the regional uptake of Tc-99m-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the performance of the PASAT task using split-dose injection of tracer. When resting and activation scans were compared there were significant decreases in tracer uptake in the right anterior cingulate and left posterior cingulate areas during PASAT activation. The findings are compared with previous studies which had implicated the anterior cingulate area in the mechanisms of attention in humans and other animals. The potentially confounding role of anxiety during attentional tasks is discussed.

AB - The effect of the paced auditory serial addition test (PASAT) on the regional uptake of Tc-99m-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the performance of the PASAT task using split-dose injection of tracer. When resting and activation scans were compared there were significant decreases in tracer uptake in the right anterior cingulate and left posterior cingulate areas during PASAT activation. The findings are compared with previous studies which had implicated the anterior cingulate area in the mechanisms of attention in humans and other animals. The potentially confounding role of anxiety during attentional tasks is discussed.

KW - PASAT

KW - SINGLE PHOTON EMISSION TOMOGRAPHY

KW - CINGULATE CORTEX

KW - ATTENTION

KW - CEREBRAL BLOOD-FLOW

KW - RECURRENT SEVERE HYPOGLYCEMIA

KW - ALZHEIMER-TYPE DEMENTIA

KW - COMPUTERIZED-TOMOGRAPHY

KW - MAJOR DEPRESSION

KW - DISEASE

KW - SPECT

KW - ANTERIOR

KW - DISORDER

M3 - Article

SN - 0301-0511

VL - 38

SP - 118

JO - Biological Psychology

JF - Biological Psychology

IS - 1

ER -

PASAT performance and the pattern of uptake of Tc-99m-exametazime in brain estimated with single photon emission tomography

Abstract

Keywords / Materials (for Non-textual outputs)

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