Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

M.E. Chase-Topping; T. Rosser; L.J. Allison; E. Courcier; J. Evans; I.J. McKendrick; M.C. Pearce; I. Handel; A. Caprioli; H. Karch; Mary Hanson; K.G. Pollock; M.E. Locking; M.E. Woolhouse; L. Matthews; J.C. Low; D.L. Gally

doi:10.3201/eid1803.111236

Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

M.E. Chase-Topping, T. Rosser, L.J. Allison, E. Courcier, J. Evans, I.J. McKendrick, M.C. Pearce, I. Handel, A. Caprioli, H. Karch, Mary Hanson, K.G. Pollock, M.E. Locking, M.E. Woolhouse, L. Matthews, J.C. Low, D.L. Gally

Research output: Contribution to journal › Article › peer-review

Abstract

Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.

Original language	English
Pages (from-to)	439-448
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	18
Issue number	3
DOIs	https://doi.org/10.3201/eid1803.111236
Publication status	Published - 2012

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Chase-Topping, M. E., Rosser, T., Allison, L. J., Courcier, E., Evans, J., McKendrick, I. J., Pearce, M. C., Handel, I., Caprioli, A., Karch, H., Hanson, M., Pollock, K. G., Locking, M. E., Woolhouse, M. E., Matthews, L., Low, J. C., & Gally, D. L. (2012). Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland. Emerging Infectious Diseases, 18(3), 439-448. https://doi.org/10.3201/eid1803.111236

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title = "Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland",

abstract = "Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.",

author = "M.E. Chase-Topping and T. Rosser and L.J. Allison and E. Courcier and J. Evans and I.J. McKendrick and M.C. Pearce and I. Handel and A. Caprioli and H. Karch and Mary Hanson and K.G. Pollock and M.E. Locking and M.E. Woolhouse and L. Matthews and J.C. Low and D.L. Gally",

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Chase-Topping, ME, Rosser, T, Allison, LJ, Courcier, E, Evans, J, McKendrick, IJ, Pearce, MC, Handel, I, Caprioli, A, Karch, H, Hanson, M, Pollock, KG, Locking, ME, Woolhouse, ME, Matthews, L, Low, JC & Gally, DL 2012, 'Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland', Emerging Infectious Diseases, vol. 18, no. 3, pp. 439-448. https://doi.org/10.3201/eid1803.111236

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T1 - Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

AU - Chase-Topping, M.E.

AU - Rosser, T.

AU - Allison, L.J.

AU - Courcier, E.

AU - Evans, J.

AU - McKendrick, I.J.

AU - Pearce, M.C.

AU - Handel, I.

AU - Caprioli, A.

AU - Karch, H.

AU - Hanson, Mary

AU - Pollock, K.G.

AU - Locking, M.E.

AU - Woolhouse, M.E.

AU - Matthews, L.

AU - Low, J.C.

AU - Gally, D.L.

N1 - 22377426 Chase-Topping, Margo E Rosser, Tracy Allison, Lesley J Courcier, Emily Evans, Judith McKendrick, Iain J Pearce, Michael C Handel, Ian Caprioli, Alfredo Karch, Helge Hanson, Mary F Pollock, Kevin G J Locking, Mary E Woolhouse, Mark E J Matthews, Louise Low, J Chris Gally, David L United States Emerging infectious diseases Emerg Infect Dis. 2012 Mar;18(3):439-48. doi: 10.3201/eid1803.111236.

PY - 2012

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N2 - Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.

AB - Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.

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U2 - 10.3201/eid1803.111236

DO - 10.3201/eid1803.111236

M3 - Article

SN - 1080-6059

VL - 18

SP - 439

EP - 448

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -

Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

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Innate immunity and endemic diseases in livestock species

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Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

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Innate immunity and endemic diseases in livestock species

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