Pathological networking: a new approach to understanding COPD

I. Sabroe*, L. C. Parker, P. M. A. Calverley, S. K. Dower, M. K. B. Whyte

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Developing new treatments for chronic obstructive pulmonary disease ( COPD) is extremely challenging. This disease, chronic by definition, becomes apparent only after substantial-and probably irreversible-tissue damage has occurred. The observable phenotype is of a stable disease state whose progression is hard to influence and reversal of which appears almost impossible. Identifying key components of the pathological process, targeting of which will result in substantial clinical benefit, is a significant challenge. In this review the nature of the disease is examined and conceptual information and simple tissue models of inflammation are used to explore the pathological network that is COPD. From the concept of COPD as a disease network displaying the features of contiguous immunity ( in which many processes of innate and adaptive immunity are in continual dialogue and evolution), refinements are suggested to the strategies aimed at developing effective new treatments for this disease.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalPostgraduate Medical Journal
Volume84
Issue number991
DOIs
Publication statusPublished - May 2008

Keywords

  • OBSTRUCTIVE PULMONARY-DISEASE
  • TOLL-LIKE RECEPTORS
  • AIR-FLOW LIMITATION
  • LUNG-DISEASE
  • GRANULOCYTE APOPTOSIS
  • INFLAMMATORY DISEASE
  • ASTHMA EXACERBATIONS
  • N-ACETYLCYSTEINE
  • EPITHELIAL-CELLS
  • CONTROLLED TRIAL

Fingerprint

Dive into the research topics of 'Pathological networking: a new approach to understanding COPD'. Together they form a unique fingerprint.

Cite this