Pathophysiologic correlations in lymphoid interstitial pneumonia

D D Collie, P M Warren, I Begara, L Luján, N J Watt

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Effective alveolar volume, diffusing capacity for carbon monoxide (DCOsb), volume-corrected diffusing capacity (D/VA), static lung compliance (Cst), and lung distensibility were measured in 16 sheep seropositive for maedi-visna virus (MVV) immediately before they were killed. Lungs were inflation-fixed, and the left lung was randomly sampled for morphometric analysis. The total lung weight, total fixed lung volume, volume densities of tissue (Vvt) and air (Vva), and the alveolar surface density were measured and correlated with the physiologic measurements. The density of surface forces could not account for the variation in the distensibility of the lungs, indicating that tissue-related forces may be important in determining lung distensibility in lymphoid interstitial pneumonia (LIP) associated with MVV infection. Possible sources of tissue-related forces are the contractile tissue associated with lung parenchyma, airways, or vasculature. When DCOsb was corrected for volume, a strong negative correlation with Vvt was noted, indicating that factors distinct from lung-volume reduction are important in limiting gas exchange in LIP associated with MVV infection. More sheep demonstrated abnormal D/VA values than any other physiologic measurement, with reduced values being apparent even in sheep considered clinically normal and with little or no morphometric evidence of lung disease. Measurements of diffusing capacity are thus considered the most sensitive functional index of disease progression.
Original languageEnglish
Pages (from-to)1575-82
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume149
Issue number6
DOIs
Publication statusPublished - Jun 1994

Keywords / Materials (for Non-textual outputs)

  • Severity of Illness Index
  • Sensitivity and Specificity
  • Animals
  • Sheep
  • Pulmonary Diffusing Capacity
  • Linear Models
  • Disease Models, Animal
  • Lymphocytes
  • Organ Size
  • Lung Compliance
  • Pneumonia, Progressive Interstitial, of Sheep
  • Carbon Monoxide
  • Lung Volume Measurements
  • Pulmonary Alveoli
  • Female
  • Surface Properties

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