Pathophysiology of Aortic Stenosis and Future Perspectives for Medical Therapy

Kang H Zheng, Evangelos Tzolos, Marc R Dweck

Research output: Contribution to journalReview articlepeer-review

Abstract

Calcific aortic valve stenosis is the commonest form of heart valve disease in high-income countries and set to become a major health care burden. Currently, there are no medical therapies that have proved to slow down or halt disease progression. The only available treatment is aortic valve replacement, of which the optimal timing is unknown and to which not all patients are suited. This review discusses the pathophysiology of aortic stenosis, how noninvasive imaging techniques have improved our understanding of the underlying biology, and how these emerging insights might translate into potential novel treatments targeting oxidized lipids, fibrosis, and calcification.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalCardiology clinics
Volume38
Issue number1
Early online date1 Nov 2019
DOIs
Publication statusPublished - Feb 2020

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