PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

Catherine Sudlow, Marina Mola-Caminal, Caty Carrera, Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Rosa M. Díaz-Navarro, Sílvia Tur, Carmen Jiménez4, Aina Medina-Dols, Natàlia Cullell, Nuria Pazos, Torres Aguila, Elena Muiño, Ana Rodríguez-Campello, Angel Ois, Elisa Cuadrado-godia, Rosa M Vivanco-Hidalgo, Mar Hernandez-Guillamon, Montse Solé, Pilar DelgadoAlejandro Bustamante, Teresa García-Berrocoso, Maite Mendióroz, Mar Castellanos, Joaquín Serena, Joan Martí-Fàbregas, Tomás Segura, Gemma Serrano-Heras, Victor Obach, Marc Ribó, Carlos A Molina , José Álvarez Sabín, Ernest Palomeras, Mar Freijo , Maria A Font, Jonathan Rosand, Natalia S Rost, Cristina Gallego-Fabrega, Jin-Moo Lee, Laura Heitsch, Laura Ibanez, Carlos Cruchaga, Chia-ling Phuah, Robin Lemmens, Vincent Thijs, Arne Lindgren, Jane Maguire, Kristiina Rannikmae, Christina Jern, Tara M Stanne, Erik Lorentzen, Lucía Muñoz-Narbona, Antonio Davalos, Elena López-Cancio, Bradford B Worrall, Daniel Woo, Steven J Kittner, Braxton D. Mitchell, Joan Montaner, Jaume Roquer, Jurek Krupinski, Xavier Estivill, Raquel Rabionet, Cristòfol Vives-Bauzá, Israel Fernandez-Cadenas, Jordi Jiménez-Conde

Research output: Contribution to journalArticlepeer-review

Abstract

RATIONALE: Ischemic stroke (IS) is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome.

OBJECTIVE: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest genome-wide association study (GWAS) in IS recovery to date.

METHODS AND RESULTS: A 12-cohort, two-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent IS cases. Functional outcome was recorded using 3-month modified Rankin Scale (mRS). Analyses were adjusted for confounders such as discharge NIHSS. A gene-based burden test was performed. The discovery phase (n=1,225) was followed by open (n=2,482) and stringent joint-analyses (n=1,791). Those cohorts with mRS recorded at timepoints other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, beta=0·40, p=1·70x10-9).

CONCLUSIONS: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci.
Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalCirculation Research
Volume124
Issue number1
Early online date15 Oct 2018
DOIs
Publication statusPublished - Jan 2019

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