Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia

S.M. Warman; J.K. Murray; A. Ridyard; J. Eastwood; S. Silva; M.J. Day

doi:10.1111/j.1748-5827.2008.00641.x

Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia

S.M. Warman, J.K. Murray, A. Ridyard, J. Eastwood, S. Silva, M.J. Day

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: To investigate the clinical significance of the pattern of Coombs' test reactivity in dogs with immune-mediated haemolytic anaemia. METHODS: Sixty-five anaemic dogs with a positive Coombs' test were included. Coombs' testing was performed at 4 and 37 degrees C with polyvalent canine Coombs' reagent and antisera specific for each of canine immunoglobulin G, immunoglobulin M and complement factor C3. The impact of performing testing with only polyvalent antiserum at 37 degrees C was assessed. Chi-squared tests were used to compare Coombs' test reactivity in dogs with primary immune-mediated haemolytic anaemia (group A) and in dogs with concurrent/ underlying disease (group B). Following Bonferroni correction, significance was set at P

Original language	English
Pages (from-to)	525-530
Number of pages	6
Journal	Journal of Small Animal Practice
Volume	49
Issue number	10
DOIs	https://doi.org/10.1111/j.1748-5827.2008.00641.x
Publication status	Published - Oct 2008

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10.1111/j.1748-5827.2008.00641.x

http://onlinelibrary.wiley.com/doi/10.1111/j.1748-5827.2008.00641.x/abstract

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title = "Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia",

abstract = "OBJECTIVES: To investigate the clinical significance of the pattern of Coombs' test reactivity in dogs with immune-mediated haemolytic anaemia. METHODS: Sixty-five anaemic dogs with a positive Coombs' test were included. Coombs' testing was performed at 4 and 37 degrees C with polyvalent canine Coombs' reagent and antisera specific for each of canine immunoglobulin G, immunoglobulin M and complement factor C3. The impact of performing testing with only polyvalent antiserum at 37 degrees C was assessed. Chi-squared tests were used to compare Coombs' test reactivity in dogs with primary immune-mediated haemolytic anaemia (group A) and in dogs with concurrent/ underlying disease (group B). Following Bonferroni correction, significance was set at P ",

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AU - Warman, S.M.

AU - Murray, J.K.

AU - Ridyard, A.

AU - Eastwood, J.

AU - Silva, S.

AU - Day, M.J.

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AB - OBJECTIVES: To investigate the clinical significance of the pattern of Coombs' test reactivity in dogs with immune-mediated haemolytic anaemia. METHODS: Sixty-five anaemic dogs with a positive Coombs' test were included. Coombs' testing was performed at 4 and 37 degrees C with polyvalent canine Coombs' reagent and antisera specific for each of canine immunoglobulin G, immunoglobulin M and complement factor C3. The impact of performing testing with only polyvalent antiserum at 37 degrees C was assessed. Chi-squared tests were used to compare Coombs' test reactivity in dogs with primary immune-mediated haemolytic anaemia (group A) and in dogs with concurrent/ underlying disease (group B). Following Bonferroni correction, significance was set at P

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Pattern of Coombs' test reactivity has diagnostic significance in dogs with immune-mediated haemolytic anaemia

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