Patterns of connectome variability in autism across five functional activation tasks: Findings from the LEAP project

Tristan Looden, Dorothea L. Floris, Alberto Llera, Roselyne J. Chauvin, Tony Charman, Tobias Banaschewski, Declan G. M. Murphy, Andre. F. Marquand, Jan K. Buitelaar, Christian F. Beckmann, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-cohen, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Carsten BoursMichael Brammer, Daniel Brandeis, Claudia Brogna, Yvette De Bruijn, Jan K. Buitelaar, Bhismadev Chakrabarti, Tony Charman, Ineke Cornelissen, Daisy Crawley, Flavio Dell’ Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Mark H. Johnson, Emily J. H. Jones, Prantik Kundu, Meng-chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, Eva Loth, David J. Lythgoe, René Mandl, Andre Marquand, Luke Mason, Maarten Mennes, Andreas Meyer-lindenberg, Carolin Moessnang, Nico Mueller, Declan G. M. Murphy, Bethany Oakley, Laurence O’dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Annika Rausch, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Julian Tillmann, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge, Iva Ilioska, Ting Mei, Marcel P. Zwiers

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background: Autism spectrum disorder (autism) is a complex neurodevelopmental condition with pronounced behavioral, cognitive, and neural heterogeneities across individuals. Here, our goal was to characterize heterogeneity in autism by identifying patterns of neural diversity as reflected in BOLD fMRI in the way individuals with autism engage with a varied array of cognitive tasks. Methods: All analyses were based on the EU-AIMS/AIMS-2-TRIALS multisite Longitudinal European Autism Project (LEAP) with participants with autism (n = 282) and typically developing (TD) controls (n = 221) between 6 and 30 years of age. We employed a novel task potency approach which combines the unique aspects of both resting state fMRI and task-fMRI to quantify task-induced variations in the functional connectome. Normative modelling was used to map atypicality of features on an individual basis with respect to their distribution in neurotypical control participants. We applied robust out-of-sample canonical correlation analysis (CCA) to relate connectome data to behavioral data. Results: Deviation from the normative ranges of global functional connectivity was greater for individuals with autism compared to TD in each fMRI task paradigm (all tasks p 
Original languageEnglish
Article number53
JournalMolecular Autism
Volume13
Early online date27 Dec 2022
DOIs
Publication statusPublished - 2022

Keywords / Materials (for Non-textual outputs)

  • autism
  • fMRI
  • functional connectivity
  • normative modeling
  • heterogeneity
  • canonical correlation analysis

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