PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Amand F Schmidt; Daniel I Swerdlow; Michael V Holmes; Riyaz S Patel; Zammy Fairhurst-hunter; Donald M Lyall; Fernando Pires Hartwig; Bernardo Lessa Horta; Elina Hyppönen; Christine Power; Max Moldovan; Erik Van Iperen; G Kees Hovingh; Ilja Demuth; Kristina Norman; Elisabeth Steinhagen-thiessen; Juri Demuth; Lars Bertram; Tian Liu; Stefan Coassin; Johann Willeit; Stefan Kiechl; Karin Willeit; Dan Mason; John Wright; Richard Morris; Goya Wanamethee; Peter Whincup; Yoav Ben-shlomo; Stela Mclachlan; Jackie F Price; Mika Kivimaki; Catherine Welch; Adelaida Sanchez-galvez; Pedro Marques-vidal; Andrew Nicolaides; Andrie G Panayiotou; N Charlotte Onland-moret; Yvonne T Van Der Schouw; Giuseppe Matullo; Giovanni Fiorito; Simonetta Guarrera; Carlotta Sacerdote; Nicholas J Wareham; Claudia Langenberg; Robert Scott; Jian'an Luan; Martin Bobak; Sofia Malyutina; Andrzej Pająk; Ruzena Kubinova; Abdonas Tamosiunas; Hynek Pikhart; Lise Lotte Nystrup Husemoen; Niels Grarup; Oluf Pedersen; Torben Hansen; Allan Linneberg; Kenneth Starup Simonsen; Jackie Cooper; Steve E Humphries; Murray Brilliant; Terrie Kitchner; Hakon Hakonarson; David S Carrell; Catherine A Mccarty; H Lester Kirchner; Eric B Larson; David R Crosslin; Mariza De Andrade; Dan M Roden; Joshua C Denny; Cara Carty; Stephen Hancock; John Attia; Elizabeth Holliday; Martin O' Donnell; Salim Yusuf; Michael Chong; Guillaume Pare; Pim Van Der Harst; M Abdullah Said; Ruben N Eppinga; Niek Verweij; Harold Snieder; Tim Christen; Dennis O Mook-kanamori; Stefan Gustafsson; Lars Lind; Erik Ingelsson; Raha Pazoki; Oscar Franco; Albert Hofman; Andre Uitterlinden; Abbas Dehghan; Alexander Teumer; Sebastian Baumeister; Marcus Dörr; Markus M Lerch; Uwe Völker; Henry Völzke; Joey Ward; Jill P Pell; Daniel J Smith; Tom Meade; Anke H Maitland-van Der Zee; Ekaterina V Baranova; Robin Young; Ian Ford; Archie Campbell; Sandosh Padmanabhan; Michiel L Bots; Diederick E Grobbee; Philippe Froguel; Dorothée Thuillier; Beverley Balkau; Amélie Bonnefond; Bertrand Cariou; Melissa Smart; Yanchun Bao; Meena Kumari; Anubha Mahajan; Paul M Ridker; Daniel I Chasman; Alex P Reiner; Leslie A Lange; Marylyn D Ritchie; Folkert W Asselbergs; Juan-pablo Casas; Brendan J Keating; David Preiss; Aroon D Hingorani; Naveed Sattar

doi:10.1016/S2213-8587(16)30396-5

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik Van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan CoassinJohann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-shlomo, Stela Mclachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-galvez, Pedro Marques-vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-moret, Yvonne T Van Der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A Mccarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza De Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim Van Der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van Der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	The Lancet Diabetes & Endocrinology
DOIs	https://doi.org/10.1016/S2213-8587(16)30396-5
Publication status	Published - 28 Nov 2016

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10.1016/S2213-8587(16)30396-5

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Cite this

Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., Van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-thiessen, E., Demuth, J., Bertram, L., Liu, T., ... Sattar, N. (2016). PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/S2213-8587(16)30396-5

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title = "PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study",

author = "Schmidt, {Amand F} and Swerdlow, {Daniel I} and Holmes, {Michael V} and Patel, {Riyaz S} and Zammy Fairhurst-hunter and Lyall, {Donald M} and Hartwig, {Fernando Pires} and Horta, {Bernardo Lessa} and Elina Hypp{\"o}nen and Christine Power and Max Moldovan and {Van Iperen}, Erik and Hovingh, {G Kees} and Ilja Demuth and Kristina Norman and Elisabeth Steinhagen-thiessen and Juri Demuth and Lars Bertram and Tian Liu and Stefan Coassin and Johann Willeit and Stefan Kiechl and Karin Willeit and Dan Mason and John Wright and Richard Morris and Goya Wanamethee and Peter Whincup and Yoav Ben-shlomo and Stela Mclachlan and Price, {Jackie F} and Mika Kivimaki and Catherine Welch and Adelaida Sanchez-galvez and Pedro Marques-vidal and Andrew Nicolaides and Panayiotou, {Andrie G} and Onland-moret, {N Charlotte} and {Van Der Schouw}, {Yvonne T} and Giuseppe Matullo and Giovanni Fiorito and Simonetta Guarrera and Carlotta Sacerdote and Wareham, {Nicholas J} and Claudia Langenberg and Robert Scott and Jian'an Luan and Martin Bobak and Sofia Malyutina and Andrzej Paj{\c a}k and Ruzena Kubinova and Abdonas Tamosiunas and Hynek Pikhart and Husemoen, {Lise Lotte Nystrup} and Niels Grarup and Oluf Pedersen and Torben Hansen and Allan Linneberg and Simonsen, {Kenneth Starup} and Jackie Cooper and Humphries, {Steve E} and Murray Brilliant and Terrie Kitchner and Hakon Hakonarson and Carrell, {David S} and Mccarty, {Catherine A} and Kirchner, {H Lester} and Larson, {Eric B} and Crosslin, {David R} and {De Andrade}, Mariza and Roden, {Dan M} and Denny, {Joshua C} and Cara Carty and Stephen Hancock and John Attia and Elizabeth Holliday and Donnell, {Martin O'} and Salim Yusuf and Michael Chong and Guillaume Pare and {Van Der Harst}, Pim and Said, {M Abdullah} and Eppinga, {Ruben N} and Niek Verweij and Harold Snieder and Tim Christen and Mook-kanamori, {Dennis O} and Stefan Gustafsson and Lars Lind and Erik Ingelsson and Raha Pazoki and Oscar Franco and Albert Hofman and Andre Uitterlinden and Abbas Dehghan and Alexander Teumer and Sebastian Baumeister and Marcus D{\"o}rr and Lerch, {Markus M} and Uwe V{\"o}lker and Henry V{\"o}lzke and Joey Ward and Pell, {Jill P} and Smith, {Daniel J} and Tom Meade and {Maitland-van Der Zee}, {Anke H} and Baranova, {Ekaterina V} and Robin Young and Ian Ford and Archie Campbell and Sandosh Padmanabhan and Bots, {Michiel L} and Grobbee, {Diederick E} and Philippe Froguel and Doroth{\'e}e Thuillier and Beverley Balkau and Am{\'e}lie Bonnefond and Bertrand Cariou and Melissa Smart and Yanchun Bao and Meena Kumari and Anubha Mahajan and Ridker, {Paul M} and Chasman, {Daniel I} and Reiner, {Alex P} and Lange, {Leslie A} and Ritchie, {Marylyn D} and Asselbergs, {Folkert W} and Juan-pablo Casas and Keating, {Brendan J} and David Preiss and Hingorani, {Aroon D} and Naveed Sattar",

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month = nov,

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doi = "10.1016/S2213-8587(16)30396-5",

language = "English",

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Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hyppönen, E, Power, C, Moldovan, M, Van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-shlomo, Y, Mclachlan, S, Price, JF, Kivimaki, M, Welch, C, Sanchez-galvez, A, Marques-vidal, P, Nicolaides, A, Panayiotou, AG, Onland-moret, NC, Van Der Schouw, YT, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, NJ, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pająk, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, LLN, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, KS, Cooper, J, Humphries, SE, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, DS, Mccarty, CA, Kirchner, HL, Larson, EB, Crosslin, DR, De Andrade, M, Roden, DM, Denny, JC, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, MO, Yusuf, S, Chong, M, Pare, G, Van Der Harst, P, Said, MA, Eppinga, RN, Verweij, N, Snieder, H, Christen, T, Mook-kanamori, DO, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, MM, Völker, U, Völzke, H, Ward, J, Pell, JP, Smith, DJ, Meade, T, Maitland-van Der Zee, AH, Baranova, EV, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, ML, Grobbee, DE, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, PM, Chasman, DI, Reiner, AP, Lange, LA, Ritchie, MD, Asselbergs, FW, Casas, J, Keating, BJ, Preiss, D, Hingorani, AD & Sattar, N 2016, 'PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study', The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/S2213-8587(16)30396-5

TY - JOUR

T1 - PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

AU - Schmidt, Amand F

AU - Swerdlow, Daniel I

AU - Holmes, Michael V

AU - Patel, Riyaz S

AU - Fairhurst-hunter, Zammy

AU - Lyall, Donald M

AU - Hartwig, Fernando Pires

AU - Horta, Bernardo Lessa

AU - Hyppönen, Elina

AU - Power, Christine

AU - Moldovan, Max

AU - Van Iperen, Erik

AU - Hovingh, G Kees

AU - Demuth, Ilja

AU - Norman, Kristina

AU - Steinhagen-thiessen, Elisabeth

AU - Demuth, Juri

AU - Bertram, Lars

AU - Liu, Tian

AU - Coassin, Stefan

AU - Willeit, Johann

AU - Kiechl, Stefan

AU - Willeit, Karin

AU - Mason, Dan

AU - Wright, John

AU - Morris, Richard

AU - Wanamethee, Goya

AU - Whincup, Peter

AU - Ben-shlomo, Yoav

AU - Mclachlan, Stela

AU - Price, Jackie F

AU - Kivimaki, Mika

AU - Welch, Catherine

AU - Sanchez-galvez, Adelaida

AU - Marques-vidal, Pedro

AU - Nicolaides, Andrew

AU - Panayiotou, Andrie G

AU - Onland-moret, N Charlotte

AU - Van Der Schouw, Yvonne T

AU - Matullo, Giuseppe

AU - Fiorito, Giovanni

AU - Guarrera, Simonetta

AU - Sacerdote, Carlotta

AU - Wareham, Nicholas J

AU - Langenberg, Claudia

AU - Scott, Robert

AU - Luan, Jian'an

AU - Bobak, Martin

AU - Malyutina, Sofia

AU - Pająk, Andrzej

AU - Kubinova, Ruzena

AU - Tamosiunas, Abdonas

AU - Pikhart, Hynek

AU - Husemoen, Lise Lotte Nystrup

AU - Grarup, Niels

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Linneberg, Allan

AU - Simonsen, Kenneth Starup

AU - Cooper, Jackie

AU - Humphries, Steve E

AU - Brilliant, Murray

AU - Kitchner, Terrie

AU - Hakonarson, Hakon

AU - Carrell, David S

AU - Mccarty, Catherine A

AU - Kirchner, H Lester

AU - Larson, Eric B

AU - Crosslin, David R

AU - De Andrade, Mariza

AU - Roden, Dan M

AU - Denny, Joshua C

AU - Carty, Cara

AU - Hancock, Stephen

AU - Attia, John

AU - Holliday, Elizabeth

AU - Donnell, Martin O'

AU - Yusuf, Salim

AU - Chong, Michael

AU - Pare, Guillaume

AU - Van Der Harst, Pim

AU - Said, M Abdullah

AU - Eppinga, Ruben N

AU - Verweij, Niek

AU - Snieder, Harold

AU - Christen, Tim

AU - Mook-kanamori, Dennis O

AU - Gustafsson, Stefan

AU - Lind, Lars

AU - Ingelsson, Erik

AU - Pazoki, Raha

AU - Franco, Oscar

AU - Hofman, Albert

AU - Uitterlinden, Andre

AU - Dehghan, Abbas

AU - Teumer, Alexander

AU - Baumeister, Sebastian

AU - Dörr, Marcus

AU - Lerch, Markus M

AU - Völker, Uwe

AU - Völzke, Henry

AU - Ward, Joey

AU - Pell, Jill P

AU - Smith, Daniel J

AU - Meade, Tom

AU - Maitland-van Der Zee, Anke H

AU - Baranova, Ekaterina V

AU - Young, Robin

AU - Ford, Ian

AU - Campbell, Archie

AU - Padmanabhan, Sandosh

AU - Bots, Michiel L

AU - Grobbee, Diederick E

AU - Froguel, Philippe

AU - Thuillier, Dorothée

AU - Balkau, Beverley

AU - Bonnefond, Amélie

AU - Cariou, Bertrand

AU - Smart, Melissa

AU - Bao, Yanchun

AU - Kumari, Meena

AU - Mahajan, Anubha

AU - Ridker, Paul M

AU - Chasman, Daniel I

AU - Reiner, Alex P

AU - Lange, Leslie A

AU - Ritchie, Marylyn D

AU - Asselbergs, Folkert W

AU - Casas, Juan-pablo

AU - Keating, Brendan J

AU - Preiss, David

AU - Hingorani, Aroon D

AU - Sattar, Naveed

PY - 2016/11/28

Y1 - 2016/11/28

U2 - 10.1016/S2213-8587(16)30396-5

DO - 10.1016/S2213-8587(16)30396-5

M3 - Article

SN - 2213-8587

JO - The Lancet Diabetes & Endocrinology

JF - The Lancet Diabetes & Endocrinology

ER -