PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease

Marco Zucchelli, Leif Torkvist, Francesca Bresso, Jonas Halfvarson, Anna Hellquist, Francesca Anedda, Ghazaleh Assadi, Gunnar B Lindgren, Monika Svanfeldt, Martin Janson, Colin L Noble, Sven Pettersson, Maarit Lappalainen, Paulina Paavola-Sakki, Leena Halme, Martti Färkkilä, Ulla Turunen, Jack Satsangi, Kimmo Kontula, Robert LöfbergJuha Kere, Mauro D'Amato

Research output: Contribution to journalArticlepeer-review

Abstract

Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.
Original languageEnglish
Pages (from-to)1562-9
Number of pages8
JournalInflammatory Bowel Diseases
Volume15
Issue number10
DOIs
Publication statusPublished - 2009

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