PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease

Marco Zucchelli; Leif Torkvist; Francesca Bresso; Jonas Halfvarson; Anna Hellquist; Francesca Anedda; Ghazaleh Assadi; Gunnar B Lindgren; Monika Svanfeldt; Martin Janson; Colin L Noble; Sven Pettersson; Maarit Lappalainen; Paulina Paavola-Sakki; Leena Halme; Martti Färkkilä; Ulla Turunen; Jack Satsangi; Kimmo Kontula; Robert Löfberg; Juha Kere; Mauro D'Amato

doi:10.1002/ibd.20963

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease

Marco Zucchelli, Leif Torkvist, Francesca Bresso, Jonas Halfvarson, Anna Hellquist, Francesca Anedda, Ghazaleh Assadi, Gunnar B Lindgren, Monika Svanfeldt, Martin Janson, Colin L Noble, Sven Pettersson, Maarit Lappalainen, Paulina Paavola-Sakki, Leena Halme, Martti Färkkilä, Ulla Turunen, Jack Satsangi, Kimmo Kontula, Robert LöfbergJuha Kere, Mauro D'Amato

Research output: Contribution to journal › Article › peer-review

Abstract

Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.

Original language	English
Pages (from-to)	1562-9
Number of pages	8
Journal	Inflammatory Bowel Diseases
Volume	15
Issue number	10
DOIs	https://doi.org/10.1002/ibd.20963
Publication status	Published - 2009

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Zucchelli, M., Torkvist, L., Bresso, F., Halfvarson, J., Hellquist, A., Anedda, F., Assadi, G., Lindgren, G. B., Svanfeldt, M., Janson, M., Noble, C. L., Pettersson, S., Lappalainen, M., Paavola-Sakki, P., Halme, L., Färkkilä, M., Turunen, U., Satsangi, J., Kontula, K., ... D'Amato, M. (2009). PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflammatory Bowel Diseases, 15(10), 1562-9. https://doi.org/10.1002/ibd.20963

Zucchelli, Marco ; Torkvist, Leif ; Bresso, Francesca ; Halfvarson, Jonas ; Hellquist, Anna ; Anedda, Francesca ; Assadi, Ghazaleh ; Lindgren, Gunnar B ; Svanfeldt, Monika ; Janson, Martin ; Noble, Colin L ; Pettersson, Sven ; Lappalainen, Maarit ; Paavola-Sakki, Paulina ; Halme, Leena ; Färkkilä, Martti ; Turunen, Ulla ; Satsangi, Jack ; Kontula, Kimmo ; Löfberg, Robert ; Kere, Juha ; D'Amato, Mauro. / PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. In: Inflammatory Bowel Diseases. 2009 ; Vol. 15, No. 10. pp. 1562-9.

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title = "PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease",

abstract = "Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.",

author = "Marco Zucchelli and Leif Torkvist and Francesca Bresso and Jonas Halfvarson and Anna Hellquist and Francesca Anedda and Ghazaleh Assadi and Lindgren, {Gunnar B} and Monika Svanfeldt and Martin Janson and Noble, {Colin L} and Sven Pettersson and Maarit Lappalainen and Paulina Paavola-Sakki and Leena Halme and Martti F{\"a}rkkil{\"a} and Ulla Turunen and Jack Satsangi and Kimmo Kontula and Robert L{\"o}fberg and Juha Kere and Mauro D'Amato",

year = "2009",

doi = "10.1002/ibd.20963",

language = "English",

volume = "15",

pages = "1562--9",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "John Wiley & Sons Inc.",

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Zucchelli, M, Torkvist, L, Bresso, F, Halfvarson, J, Hellquist, A, Anedda, F, Assadi, G, Lindgren, GB, Svanfeldt, M, Janson, M, Noble, CL, Pettersson, S, Lappalainen, M, Paavola-Sakki, P, Halme, L, Färkkilä, M, Turunen, U, Satsangi, J, Kontula, K, Löfberg, R, Kere, J & D'Amato, M 2009, 'PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease', Inflammatory Bowel Diseases, vol. 15, no. 10, pp. 1562-9. https://doi.org/10.1002/ibd.20963

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. / Zucchelli, Marco; Torkvist, Leif; Bresso, Francesca; Halfvarson, Jonas; Hellquist, Anna; Anedda, Francesca; Assadi, Ghazaleh; Lindgren, Gunnar B; Svanfeldt, Monika; Janson, Martin; Noble, Colin L; Pettersson, Sven; Lappalainen, Maarit; Paavola-Sakki, Paulina; Halme, Leena; Färkkilä, Martti; Turunen, Ulla; Satsangi, Jack; Kontula, Kimmo; Löfberg, Robert; Kere, Juha; D'Amato, Mauro.

In: Inflammatory Bowel Diseases, Vol. 15, No. 10, 2009, p. 1562-9.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease

AU - Zucchelli, Marco

AU - Torkvist, Leif

AU - Bresso, Francesca

AU - Halfvarson, Jonas

AU - Hellquist, Anna

AU - Anedda, Francesca

AU - Assadi, Ghazaleh

AU - Lindgren, Gunnar B

AU - Svanfeldt, Monika

AU - Janson, Martin

AU - Noble, Colin L

AU - Pettersson, Sven

AU - Lappalainen, Maarit

AU - Paavola-Sakki, Paulina

AU - Halme, Leena

AU - Färkkilä, Martti

AU - Turunen, Ulla

AU - Satsangi, Jack

AU - Kontula, Kimmo

AU - Löfberg, Robert

AU - Kere, Juha

AU - D'Amato, Mauro

PY - 2009

Y1 - 2009

N2 - Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.

AB - Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in CD. Hence, we tested SLC15A1 polymorphisms for association with IBD.

U2 - 10.1002/ibd.20963

DO - 10.1002/ibd.20963

M3 - Article

C2 - 19462432

VL - 15

SP - 1562

EP - 1569

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 10

ER -

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease

Abstract

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