Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

Maria Rodriguez-rios; Alicia Megia-fernandez; Daniel J. Norman; Mark Bradley

doi:10.1039/D1CS00798J

Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

Maria Rodriguez-rios, Alicia Megia-fernandez, Daniel J. Norman, Mark Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo.

Original language	English
Journal	Chemical Society Reviews
Early online date	21 Feb 2022
DOIs	https://doi.org/10.1039/D1CS00798J
Publication status	E-pub ahead of print - 21 Feb 2022

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10.1039/D1CS00798J

20220225_Bradley_AAMAccepted author manuscript, 5.28 MB
20220701_Bradley_d1cs00798j-VoRFinal published version, 17.2 MBLicence: Creative Commons: Attribution (CC-BY)

http://xlink.rsc.org/?DOI=D1CS00798J

EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond
Bradley, M. (Principal Investigator), Bradley, M. (Principal Investigator), Dhaliwal, K. (Co-investigator), Dhaliwal, K. (Co-investigator), Haslett, C. (Co-investigator), Henderson, R. (Co-investigator), Walsh, T. (Co-investigator) & Walsh, T. (Co-investigator)
Engineering and Physical Sciences Research Council
1/01/19 → 1/06/23
Project: Research

Cite this

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title = "Peptide probes for proteases – innovations and applications for monitoring proteolytic activity",

abstract = "Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo.",

author = "Maria Rodriguez-rios and Alicia Megia-fernandez and Norman, \{Daniel J.\} and Mark Bradley",

note = "Funding Information: We would like to thank the Engineering and Physical Sciences. Research Council (EPSRC, UK) for Interdisciplinary Research Collaboration grant EP/R005257/1. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry",

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language = "English",

journal = "Chemical Society Reviews",

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T1 - Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

AU - Rodriguez-rios, Maria

AU - Megia-fernandez, Alicia

AU - Norman, Daniel J.

AU - Bradley, Mark

N1 - Funding Information: We would like to thank the Engineering and Physical Sciences. Research Council (EPSRC, UK) for Interdisciplinary Research Collaboration grant EP/R005257/1. Publisher Copyright: © 2022 The Royal Society of Chemistry

PY - 2022/2/21

Y1 - 2022/2/21

N2 - Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo.

AB - Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo.

U2 - 10.1039/D1CS00798J

DO - 10.1039/D1CS00798J

M3 - Article

SN - 0306-0012

JO - Chemical Society Reviews

JF - Chemical Society Reviews

ER -

Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

Abstract

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Projects

EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond

Cite this