Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin

Jaskiranjit Kang, Natalie Reynolds, Christine Tyrrell, Julia R Dorin, Derek Macmillan

Research output: Contribution to journalArticlepeer-review

Abstract

Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.
Original languageEnglish
Pages (from-to)4918-23
Number of pages6
JournalOrganic & Biomolecular chemistry
Volume7
Issue number23
DOIs
Publication statusPublished - 2009

Keywords

  • Esters
  • Molecular Structure
  • Sulfhydryl Compounds
  • Time Factors
  • beta-Defensins

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