Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin

Jaskiranjit Kang; Natalie Reynolds; Christine Tyrrell; Julia R Dorin; Derek Macmillan

doi:10.1039/b913886b

Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin

Jaskiranjit Kang, Natalie Reynolds, Christine Tyrrell, Julia R Dorin, Derek Macmillan

Research output: Contribution to journal › Article › peer-review

Abstract

Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.

Original language	English
Pages (from-to)	4918-23
Number of pages	6
Journal	Organic & Biomolecular chemistry
Volume	7
Issue number	23
DOIs	https://doi.org/10.1039/b913886b
Publication status	Published - 2009

Keywords

Esters
Molecular Structure
Sulfhydryl Compounds
Time Factors
beta-Defensins

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10.1039/b913886b

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title = "Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin",

abstract = "Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.",

keywords = "Esters, Molecular Structure, Sulfhydryl Compounds, Time Factors, beta-Defensins",

author = "Jaskiranjit Kang and Natalie Reynolds and Christine Tyrrell and Dorin, {Julia R} and Derek Macmillan",

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doi = "10.1039/b913886b",

language = "English",

volume = "7",

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journal = "Organic & Biomolecular chemistry",

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publisher = "Royal Society of Chemistry",

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AU - Kang, Jaskiranjit

AU - Reynolds, Natalie

AU - Tyrrell, Christine

AU - Dorin, Julia R

AU - Macmillan, Derek

PY - 2009

Y1 - 2009

N2 - Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.

AB - Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.

KW - Esters

KW - Molecular Structure

KW - Sulfhydryl Compounds

KW - Time Factors

KW - beta-Defensins

U2 - 10.1039/b913886b

DO - 10.1039/b913886b

M3 - Article

C2 - 19907782

VL - 7

SP - 4918

EP - 4923

JO - Organic & Biomolecular chemistry

JF - Organic & Biomolecular chemistry

SN - 1477-0520

IS - 23

ER -

Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin

Abstract

Keywords

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