Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

Juan J. Diaz-Mochon; Mario A. Fara; Rosario M. Sanchez-Martin; Mark Bradley

doi:10.1016/j.tetiet.2007.11.122

Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

Juan J. Diaz-Mochon, Mario A. Fara, Rosario M. Sanchez-Martin, Mark Bradley

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	923-926
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/j.tetiet.2007.11.122
Publication status	Published - 28 Jan 2008

Keywords / Materials (for Non-textual outputs)

COMBINATORIAL CHEMISTRY
PEPTIDES
POLYMERS
MONOMERS
DELIVERY
ASSAYS
GENE

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10.1016/j.tetiet.2007.11.122

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title = "Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation",

abstract = "Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.",

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author = "Diaz-Mochon, {Juan J.} and Fara, {Mario A.} and Sanchez-Martin, {Rosario M.} and Mark Bradley",

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T1 - Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

AU - Diaz-Mochon, Juan J.

AU - Fara, Mario A.

AU - Sanchez-Martin, Rosario M.

AU - Bradley, Mark

PY - 2008/1/28

Y1 - 2008/1/28

N2 - Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

AB - Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

KW - COMBINATORIAL CHEMISTRY

KW - PEPTIDES

KW - POLYMERS

KW - MONOMERS

KW - DELIVERY

KW - ASSAYS

KW - GENE

UR - http://www.scopus.com/inward/record.url?scp=37649020444&partnerID=8YFLogxK

U2 - 10.1016/j.tetiet.2007.11.122

DO - 10.1016/j.tetiet.2007.11.122

M3 - Article

SN - 0040-4039

VL - 49

SP - 923

EP - 926

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

ER -

Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

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Keywords / Materials (for Non-textual outputs)

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