Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

Juan J. Diaz-Mochon, Mario A. Fara, Rosario M. Sanchez-Martin, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)923-926
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number5
DOIs
Publication statusPublished - 28 Jan 2008

Keywords

  • COMBINATORIAL CHEMISTRY
  • PEPTIDES
  • POLYMERS
  • MONOMERS
  • DELIVERY
  • ASSAYS
  • GENE

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