PERCC1, a new member of the YAP/TAZ/FAM181 transcriptional co-regulator family

Luis Sanchez-Pulido*, Siyang Jia, Carsten Gram Hansen, Chris P Ponting

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Motivation

Disrupted PERCC1 gene expression causes an intractable congenital diarrhoea in infants. However, this gene’s molecular mechanism is unknown and no homologous proteins have been reported.
Results

Our detailed evolutionary analysis of PERCC1 sequence reveals it to be a previously unappreciated member of the YAP/TAZ/FAM181 family of homologous transcriptional regulators. Like YAP and TAZ, PERCC1 likely interacts with DNA via binding to TEA/ATTS domain transcription factors (TEADs) using its conserved interface-2 and -3 sequences. We compare the expression patterns of PERCC1 with those of YAP, TAZ, TEADs. Our report provides the identification and first in-depth bioinformatic analysis of a YAP/TAZ homologue, and a likely new regulator of the YAP/TAZ-TEAD transcriptional complex.
Original languageEnglish
Article numbervbac008
JournalAdvances in Bioinformatics
Volume2
Issue number1
Early online date3 Feb 2022
DOIs
Publication statusE-pub ahead of print - 3 Feb 2022

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