Performance evaluation of the nanoScan® P123S total-body PET.

Dániel Réti; Carlos-Alcaide Corral; Islay Cranston; Victoria J M Reid; Kerry M O'Rourke; Timaeus E F Morgan; Axel Montagne; Maurits A Jansen; Valeria K Burianova; Andrew Sutherland; Péter Major; Kálmán Nagy; Gergő Bagaméry; Adriana A S Tavares

doi:10.1186/s40658-025-00817-5

Performance evaluation of the nanoScan® P123S total-body PET.

Dániel Réti^*, Carlos-Alcaide Corral, Islay Cranston, Victoria J M Reid, Kerry M O'Rourke, Timaeus E F Morgan, Axel Montagne, Maurits A Jansen, Valeria K Burianova, Andrew Sutherland, Péter Major, Kálmán Nagy, Gergő Bagaméry, Adriana A S Tavares

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Before utilising preclinical Position Emission Tomography (PET) systems for biological studies, evaluating their performance is important to better qualify the scanner's applications. This study aims to assess the performance of the new extended field of view (FOV) nanoScan® PET/CT P123S system, developed for rodent total-body PET applications.

METHODS: Scanner resolution, noise equivalent count rate (NECR), sensitivity and image quality were evaluated following NEMA NU-4 2008 protocols. Furthermore, a Derenzo phantom and linearity measurements were conducted. In vivo studies were subsequently carried out to evaluate system performance in biological applications.

RESULTS: The scanner spatial resolution according to the NEMA protocol was 1.4 mm using FBP reconstruction, while with iterative reconstruction it was under 0.7 mm. The NECR peak using a 250‒750 keV energy window was 1805.0 kcps at 93.7 MBq and 880.7 kcps at 88.4 MBq for the mouse-sized and rat-sized phantom respectively. The absolute sensitivity was 10.5%. The standard deviation of the uniform area of the image quality phantom was 1.8%, while the recovery coefficients varied between 0.23 and 1.00. The spill-over ratios were 0.04, and 0.04 in the water and air-filled chambers respectively. Quantitative bias was < 4% with a linear response up to 105 MBq. Total-body rat images were successfully acquired using the new system.

CONCLUSION: The new extended FOV PET system has improved sensitivity and count rate performance compared with previous systems. Its spatial resolution and quantitative accuracy are well-suited for preclinical PET applications. The extended FOV enables total-body imaging of both mice and rats.

Original language	English
Pages (from-to)	2
Journal	EJNMMI physics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s40658-025-00817-5
Publication status	Published - 8 Dec 2025

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10.1186/s40658-025-00817-5

s40658-025-00817-5Final published version, 5.01 MBLicence: Creative Commons: Attribution (CC-BY)

Edinburgh Preclinical Imaging
Moran, C. (Manager), Thomson, A. (Manager), Lennen, R. J. (Manager), Tavares, A. (Manager), Alcaide-Corral, C. J. (Manager), Morgan, T. (Other), Cranston, I. (Other) & O'Rourke, K. (Other)
School of Neurological and Cardiovascular Sciences
Facility/equipment: Facility

Cite this

@article{8ea995bbd8fc48089f48c124325cff18,

title = "Performance evaluation of the nanoScan{\textregistered} P123S total-body PET.",

abstract = "PURPOSE: Before utilising preclinical Position Emission Tomography (PET) systems for biological studies, evaluating their performance is important to better qualify the scanner's applications. This study aims to assess the performance of the new extended field of view (FOV) nanoScan{\textregistered} PET/CT P123S system, developed for rodent total-body PET applications.METHODS: Scanner resolution, noise equivalent count rate (NECR), sensitivity and image quality were evaluated following NEMA NU-4 2008 protocols. Furthermore, a Derenzo phantom and linearity measurements were conducted. In vivo studies were subsequently carried out to evaluate system performance in biological applications.RESULTS: The scanner spatial resolution according to the NEMA protocol was 1.4 mm using FBP reconstruction, while with iterative reconstruction it was under 0.7 mm. The NECR peak using a 250‒750 keV energy window was 1805.0 kcps at 93.7 MBq and 880.7 kcps at 88.4 MBq for the mouse-sized and rat-sized phantom respectively. The absolute sensitivity was 10.5\%. The standard deviation of the uniform area of the image quality phantom was 1.8\%, while the recovery coefficients varied between 0.23 and 1.00. The spill-over ratios were 0.04, and 0.04 in the water and air-filled chambers respectively. Quantitative bias was < 4\% with a linear response up to 105 MBq. Total-body rat images were successfully acquired using the new system.CONCLUSION: The new extended FOV PET system has improved sensitivity and count rate performance compared with previous systems. Its spatial resolution and quantitative accuracy are well-suited for preclinical PET applications. The extended FOV enables total-body imaging of both mice and rats.",

author = "D{\'a}niel R{\'e}ti and Carlos-Alcaide Corral and Islay Cranston and Reid, \{Victoria J M\} and O'Rourke, \{Kerry M\} and Morgan, \{Timaeus E F\} and Axel Montagne and Jansen, \{Maurits A\} and Burianova, \{Valeria K\} and Andrew Sutherland and P{\'e}ter Major and K{\'a}lm{\'a}n Nagy and Gerg{\H o} Bagam{\'e}ry and Tavares, \{Adriana A S\}",

note = "{\textcopyright} 2025. The Author(s).",

year = "2025",

month = dec,

day = "8",

doi = "10.1186/s40658-025-00817-5",

language = "English",

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journal = "EJNMMI physics",

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T1 - Performance evaluation of the nanoScan® P123S total-body PET.

AU - Réti, Dániel

AU - Corral, Carlos-Alcaide

AU - Cranston, Islay

AU - Reid, Victoria J M

AU - O'Rourke, Kerry M

AU - Morgan, Timaeus E F

AU - Montagne, Axel

AU - Jansen, Maurits A

AU - Burianova, Valeria K

AU - Sutherland, Andrew

AU - Major, Péter

AU - Nagy, Kálmán

AU - Bagaméry, Gergő

AU - Tavares, Adriana A S

PY - 2025/12/8

Y1 - 2025/12/8

N2 - PURPOSE: Before utilising preclinical Position Emission Tomography (PET) systems for biological studies, evaluating their performance is important to better qualify the scanner's applications. This study aims to assess the performance of the new extended field of view (FOV) nanoScan® PET/CT P123S system, developed for rodent total-body PET applications.METHODS: Scanner resolution, noise equivalent count rate (NECR), sensitivity and image quality were evaluated following NEMA NU-4 2008 protocols. Furthermore, a Derenzo phantom and linearity measurements were conducted. In vivo studies were subsequently carried out to evaluate system performance in biological applications.RESULTS: The scanner spatial resolution according to the NEMA protocol was 1.4 mm using FBP reconstruction, while with iterative reconstruction it was under 0.7 mm. The NECR peak using a 250‒750 keV energy window was 1805.0 kcps at 93.7 MBq and 880.7 kcps at 88.4 MBq for the mouse-sized and rat-sized phantom respectively. The absolute sensitivity was 10.5%. The standard deviation of the uniform area of the image quality phantom was 1.8%, while the recovery coefficients varied between 0.23 and 1.00. The spill-over ratios were 0.04, and 0.04 in the water and air-filled chambers respectively. Quantitative bias was < 4% with a linear response up to 105 MBq. Total-body rat images were successfully acquired using the new system.CONCLUSION: The new extended FOV PET system has improved sensitivity and count rate performance compared with previous systems. Its spatial resolution and quantitative accuracy are well-suited for preclinical PET applications. The extended FOV enables total-body imaging of both mice and rats.

AB - PURPOSE: Before utilising preclinical Position Emission Tomography (PET) systems for biological studies, evaluating their performance is important to better qualify the scanner's applications. This study aims to assess the performance of the new extended field of view (FOV) nanoScan® PET/CT P123S system, developed for rodent total-body PET applications.METHODS: Scanner resolution, noise equivalent count rate (NECR), sensitivity and image quality were evaluated following NEMA NU-4 2008 protocols. Furthermore, a Derenzo phantom and linearity measurements were conducted. In vivo studies were subsequently carried out to evaluate system performance in biological applications.RESULTS: The scanner spatial resolution according to the NEMA protocol was 1.4 mm using FBP reconstruction, while with iterative reconstruction it was under 0.7 mm. The NECR peak using a 250‒750 keV energy window was 1805.0 kcps at 93.7 MBq and 880.7 kcps at 88.4 MBq for the mouse-sized and rat-sized phantom respectively. The absolute sensitivity was 10.5%. The standard deviation of the uniform area of the image quality phantom was 1.8%, while the recovery coefficients varied between 0.23 and 1.00. The spill-over ratios were 0.04, and 0.04 in the water and air-filled chambers respectively. Quantitative bias was < 4% with a linear response up to 105 MBq. Total-body rat images were successfully acquired using the new system.CONCLUSION: The new extended FOV PET system has improved sensitivity and count rate performance compared with previous systems. Its spatial resolution and quantitative accuracy are well-suited for preclinical PET applications. The extended FOV enables total-body imaging of both mice and rats.

U2 - 10.1186/s40658-025-00817-5

DO - 10.1186/s40658-025-00817-5

M3 - Article

C2 - 41359287

SN - 2197-7364

VL - 13

SP - 2

JO - EJNMMI physics

JF - EJNMMI physics

IS - 1

ER -

Performance evaluation of the nanoScan® P123S total-body PET.

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