TY - JOUR
T1 - Perifosine mechanisms of action in Leishmania species
AU - López-Arencibia, Atteneri
AU - Martín-Navarro, Carmen
AU - Sifaoui, Ines
AU - Reyes-Batlle, María
AU - Wagner, Carolina
AU - Lorenzo-Morales, Jacob
AU - Maciver, Sutherland K.
AU - Piñero, José E
N1 - Copyright © 2017 American Society for Microbiology.
PY - 2017/1/17
Y1 - 2017/1/17
N2 - The mechanism by which perifosine induced cell death in Leishmania donovani and L. amazonensis is described in this study. The drug reduced Leishmania mitochondrial membrane potential, decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine, as an alternative to miltefosine, against Leishmania.
AB - The mechanism by which perifosine induced cell death in Leishmania donovani and L. amazonensis is described in this study. The drug reduced Leishmania mitochondrial membrane potential, decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine, as an alternative to miltefosine, against Leishmania.
U2 - 10.1128/AAC.02127-16
DO - 10.1128/AAC.02127-16
M3 - Article
C2 - 28096161
SN - 0066-4804
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
ER -