Perifosine mechanisms of action in Leishmania species

Atteneri López-Arencibia, Carmen Martín-Navarro, Ines Sifaoui, María Reyes-Batlle, Carolina Wagner, Jacob Lorenzo-Morales, Sutherland K. Maciver, José E Piñero

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The mechanism by which perifosine induced cell death in Leishmania donovani and L. amazonensis is described in this study. The drug reduced Leishmania mitochondrial membrane potential, decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine, as an alternative to miltefosine, against Leishmania.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
DOIs
Publication statusPublished - 17 Jan 2017

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