Peripheral blood gene expression profile of infants with atopic dermatitis

Janna Nousbeck; Maeve A. McAleer; Alan D. Irvine

doi:10.1016/j.xjidi.2022.100165

Peripheral blood gene expression profile of infants with atopic dermatitis

Janna Nousbeck, Maeve A. McAleer, Alan D. Irvine

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Abstract / Description of output

To enhance the understanding of molecular mechanisms and mine previously unidentified biomarkers of pediatric atopic dermatitis, PBMC gene expression profiles were generated by RNA sequencing in infants with atopic dermatitis and age-matched controls. A total of 178 significantly differentially expressed genes (DEGs) (115 upregulations and 63 downregulations) were seen, compared with those in healthy controls. The DEGs identified included IL1β, TNF, TREM1, IL18R1, and IL18RAP. DEGs were validated by real-time RT- qPCR in a larger number of samples from PBMCs of infants with atopic dermatitis aged

Original language	English
Article number	100165
Pages (from-to)	100165
Number of pages	37
Journal	JID Innovations
Volume	3
Issue number	2
Early online date	7 Oct 2022
DOIs	https://doi.org/10.1016/j.xjidi.2022.100165
Publication status	Published - 1 Mar 2023

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title = "Peripheral blood gene expression profile of infants with atopic dermatitis",

abstract = "To enhance the understanding of molecular mechanisms and mine previously unidentified biomarkers of pediatric atopic dermatitis, PBMC gene expression profiles were generated by RNA sequencing in infants with atopic dermatitis and age-matched controls. A total of 178 significantly differentially expressed genes (DEGs) (115 upregulations and 63 downregulations) were seen, compared with those in healthy controls. The DEGs identified included IL1β, TNF, TREM1, IL18R1, and IL18RAP. DEGs were validated by real-time RT- qPCR in a larger number of samples from PBMCs of infants with atopic dermatitis aged ",

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Peripheral blood gene expression profile of infants with atopic dermatitis

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