Peripheral venous and arterial lactate agreement in septic patients in the emergency department: a pilot study

Robert Browning, Deepankar Datta*, Alasdair J Gray, Catriona Graham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Lactate measurements are routinely used in sepsis for prognostication and for guiding treatment. Although venous lactate measurements have widely been used, most studies have used arterial lactate (A-LACT). The interchangeability between the measurements is debatable. This pilot study aimed to investigate whether an agreement exists between peripheral venous lactate (PV-LACT) and A-LACT with respect to sepsis in the Emergency Department (ED). PV-LACT lactate and A-LACT measurements were taken from a convenience sample of 37 patients presenting to a tertiary hospital ED between November 2010 and August 2011. The agreement between the paired measurements was assessed using Bland-Altman analysis. The mean difference between the measurements (venous-arterial) was 0.54 mmol/l, with 95% limits of agreement of -0.11 to 1.18 mmol/l. This pilot study demonstrates the potential use of PV-LACT as a substitute for A-LACT measurement in septic ED patients. However, further definitive investigation is needed to support widespread clinical adoption of peripheral venous lactate.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalEuropean journal of emergency medicine : official journal of the European Society for Emergency Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Arteries
  • Emergency Service, Hospital
  • Female
  • Humans
  • Lactic Acid
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Sepsis
  • Veins

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