Perivascular Multipotent Progenitor Cells in Human Organs

Mihaela Crisan, Chien-Wen Chen, Mirko Corselli, Gabriella Andriolo, Lorenza Lazzari, Bruno Peault

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

Original languageEnglish
Title of host publicationHEMATOPOIETIC STEM CELLS VII
EditorsL Kanz, KC Weisel, JE Dick, WE Fibbe
Place of PublicationOXFORD
PublisherWiley-Blackwell
Pages118-123
Number of pages6
ISBN (Print)978-1-57331-761-0
Publication statusPublished - 2009
Event7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells - Meersburg
Duration: 18 Sept 200820 Sept 2008

Conference

Conference7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells
CityMeersburg
Period18/09/0820/09/08

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