Perivascular Multipotent Progenitor Cells in Human Organs

Mihaela Crisan; Chien-Wen Chen; Mirko Corselli; Gabriella Andriolo; Lorenza Lazzari; Bruno Peault

Perivascular Multipotent Progenitor Cells in Human Organs

Mihaela Crisan, Chien-Wen Chen, Mirko Corselli, Gabriella Andriolo, Lorenza Lazzari, Bruno Peault

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

Original language	English
Title of host publication	HEMATOPOIETIC STEM CELLS VII
Editors	L Kanz, KC Weisel, JE Dick, WE Fibbe
Place of Publication	OXFORD
Publisher	Wiley-Blackwell
Pages	118-123
Number of pages	6
ISBN (Print)	978-1-57331-761-0
Publication status	Published - 2009
Event	7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells - Meersburg Duration: 18 Sep 2008 → 20 Sep 2008

Conference

Conference	7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells
City	Meersburg
Period	18/09/08 → 20/09/08

Cite this

@inproceedings{556378961d0d4096a957c34d726edc98,

title = "Perivascular Multipotent Progenitor Cells in Human Organs",

abstract = "We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.",

author = "Mihaela Crisan and Chien-Wen Chen and Mirko Corselli and Gabriella Andriolo and Lorenza Lazzari and Bruno Peault",

year = "2009",

language = "English",

isbn = "978-1-57331-761-0",

pages = "118--123",

editor = "L Kanz and KC Weisel and JE Dick and WE Fibbe",

booktitle = "HEMATOPOIETIC STEM CELLS VII",

publisher = "Wiley-Blackwell",

address = "United Kingdom",

note = "7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells ; Conference date: 18-09-2008 Through 20-09-2008",

}

TY - GEN

T1 - Perivascular Multipotent Progenitor Cells in Human Organs

AU - Crisan, Mihaela

AU - Chen, Chien-Wen

AU - Corselli, Mirko

AU - Andriolo, Gabriella

AU - Lazzari, Lorenza

AU - Peault, Bruno

PY - 2009

Y1 - 2009

N2 - We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

AB - We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-R beta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

M3 - Conference contribution

SN - 978-1-57331-761-0

SP - 118

EP - 123

BT - HEMATOPOIETIC STEM CELLS VII

A2 - Kanz, L

A2 - Weisel, KC

A2 - Dick, JE

A2 - Fibbe, WE

PB - Wiley-Blackwell

CY - OXFORD

T2 - 7th Biennial International Symposium and Workshop on Hematopoietic Stem Cells

Y2 - 18 September 2008 through 20 September 2008

ER -

Perivascular Multipotent Progenitor Cells in Human Organs

Abstract

Conference

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