Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators; Alvar Agustí; Lisa D Edwards; Stephen I Rennard; William Macnee; Ruth Tal-Singer; Bruce E Miller; Jørgen Vestbo; David A Lomas; Peter M A Calverley; Emiel Wouters; Courtney Crim; Julie C Yates; Edwin K Silverman; Harvey O Coxson; Per Bakke; Ruth J Mayer; Bartolome Celli

doi:10.1371/journal.pone.0037483

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, Alvar Agustí, Lisa D Edwards, Stephen I Rennard, William Macnee, Ruth Tal-Singer, Bruce E Miller, Jørgen Vestbo, David A Lomas, Peter M A Calverley, Emiel Wouters, Courtney Crim, Julie C Yates, Edwin K Silverman, Harvey O Coxson, Per Bakke, Ruth J Mayer, Bartolome Celli

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BACKGROUND: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552). METHODS AND FINDINGS: Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% had persistent systemic inflammation. Even though pulmonary abnormalities were similar in these two groups, persistently inflamed patients during follow-up had significantly increased all-cause mortality (13% vs. 2%, p

Original language	English
Pages (from-to)	e37483
Journal	PLoS ONE
Volume	7
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0037483
Publication status	Published - 2012

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10.1371/journal.pone.0037483

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD
Copyright: © 2012 Agustí et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037483

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J.
MRC
1/09/12 → 31/08/16
Project: Research

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for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, Agustí, A., Edwards, L. D., Rennard, S. I., Macnee, W., Tal-Singer, R., Miller, B. E., Vestbo, J., Lomas, D. A., Calverley, P. M. A., Wouters, E., Crim, C., Yates, J. C., Silverman, E. K., Coxson, H. O., Bakke, P., Mayer, R. J., & Celli, B. (2012). Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype. PLoS ONE, 7(5), e37483. https://doi.org/10.1371/journal.pone.0037483

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abstract = "BACKGROUND: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552). METHODS AND FINDINGS: Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% had persistent systemic inflammation. Even though pulmonary abnormalities were similar in these two groups, persistently inflamed patients during follow-up had significantly increased all-cause mortality (13% vs. 2%, p",

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for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, Agustí, A, Edwards, LD, Rennard, SI, Macnee, W, Tal-Singer, R, Miller, BE, Vestbo, J, Lomas, DA, Calverley, PMA, Wouters, E, Crim, C, Yates, JC, Silverman, EK, Coxson, HO, Bakke, P, Mayer, RJ & Celli, B 2012, 'Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype', PLoS ONE, vol. 7, no. 5, pp. e37483. https://doi.org/10.1371/journal.pone.0037483

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T1 - Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD

T2 - A Novel Phenotype

AU - for the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

AU - Agustí, Alvar

AU - Edwards, Lisa D

AU - Rennard, Stephen I

AU - Macnee, William

AU - Tal-Singer, Ruth

AU - Miller, Bruce E

AU - Vestbo, Jørgen

AU - Lomas, David A

AU - Calverley, Peter M A

AU - Wouters, Emiel

AU - Crim, Courtney

AU - Yates, Julie C

AU - Silverman, Edwin K

AU - Coxson, Harvey O

AU - Bakke, Per

AU - Mayer, Ruth J

AU - Celli, Bartolome

PY - 2012

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AB - BACKGROUND: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552). METHODS AND FINDINGS: Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% had persistent systemic inflammation. Even though pulmonary abnormalities were similar in these two groups, persistently inflamed patients during follow-up had significantly increased all-cause mortality (13% vs. 2%, p

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DO - 10.1371/journal.pone.0037483

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SP - e37483

JO - PLoS ONE

JF - PLoS ONE

IS - 5

ER -

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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