Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Tom Booth; Rene Mõttus; Janie Corley; Alan J Gow; Ross D Henderson; Susana Munoz-Maniega; Catherine Murray; Natalie A Royle; Emma Sprooten; Maria C Valdés Hernández; Mark E Bastin; Lars Penke; John M Starr; Joanna M Wardlaw; Ian J Deary

doi:10.1037/hea0000012

Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Tom Booth^*, Rene Mõttus, Janie Corley, Alan J Gow, Ross D Henderson, Susana Munoz-Maniega, Catherine Murray, Natalie A Royle, Emma Sprooten, Maria C Valdés Hernández, Mark E Bastin, Lars Penke, John M Starr, Joanna M Wardlaw, Ian J Deary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure, a 5-factor public-domain personality measure (http://ipip.ori.org), and underwent a structural magnetic resonance brain scan at the mean age of 73 years, yielding 3 measures of whole brain integrity: average white matter fractional anisotropy (FA), brain-tissue loss, and white matter hyperintensities (N = 529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain-tissue loss (β = -0.11, p

Original language	English
Pages (from-to)	1477-1486
Number of pages	10
Journal	Health Psychology
Volume	33
Issue number	12
Early online date	18 Nov 2013
DOIs	https://doi.org/10.1037/hea0000012
Publication status	Published - Dec 2014

Keywords / Materials (for Non-textual outputs)

five-factor model
brain volume
white matter hyperintensities
fractional anisotropy
health behaviors
BODY-MASS INDEX
WHITE-MATTER INTEGRITY
6-YEAR FOLLOW-UP
ALZHEIMERS-DISEASE
PHYSICAL-ACTIVITY
OLDER-ADULTS
AGE
TRAITS
SAMPLE
VOLUME

Access to Document

10.1037/hea0000012

Booth Mottus 1936 - Health Psychology
© Personality, Health, and Brain Integrity : The Lothian Birth Cohort Study 1936. / Booth, Tom; Mõttus, Rene; Corley, Janie; Gow, Alan J; Henderson, Ross D; Munoz-Maniega, Susana; Murray, Catherine; Royle, Natalie A; Sprooten, Emma; Hernández, Maria C Valdés; Bastin, Mark E; Penke, Lars; Starr, John M; Wardlaw, Joanna M; Deary, Ian J. In: Health Psychology, 2013. Research output: Contribution to journal › Article
Accepted author manuscript, 1.47 MB

http://psycnet.apa.org/index.cfm?fa=search.displayrecord&uid=2013-39890-001

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I., Bastin, M., Penke, L., Starr, J. & Wardlaw, J.
MRC
8/06/11 → 7/03/15
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J.
UK-based charities
1/01/11 → 31/03/16
Project: Research

Cite this

Booth, T., Mõttus, R., Corley, J., Gow, A. J., Henderson, R. D., Munoz-Maniega, S., Murray, C., Royle, N. A., Sprooten, E., Hernández, M. C. V., Bastin, M. E., Penke, L., Starr, J. M., Wardlaw, J. M., & Deary, I. J. (2014). Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936. Health Psychology, 33(12), 1477-1486. https://doi.org/10.1037/hea0000012

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abstract = "Objective: To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure, a 5-factor public-domain personality measure (http://ipip.ori.org), and underwent a structural magnetic resonance brain scan at the mean age of 73 years, yielding 3 measures of whole brain integrity: average white matter fractional anisotropy (FA), brain-tissue loss, and white matter hyperintensities (N = 529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain-tissue loss (β = -0.11, p ",

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author = "Tom Booth and Rene M{\~o}ttus and Janie Corley and Gow, {Alan J} and Henderson, {Ross D} and Susana Munoz-Maniega and Catherine Murray and Royle, {Natalie A} and Emma Sprooten and Hern{\'a}ndez, {Maria C Vald{\'e}s} and Bastin, {Mark E} and Lars Penke and Starr, {John M} and Wardlaw, {Joanna M} and Deary, {Ian J}",

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AU - Murray, Catherine

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AU - Hernández, Maria C Valdés

AU - Bastin, Mark E

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Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Disconnected Mind [Phase 2]

Cite this