Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Tom Booth; Rene Mõttus; Janie Corley; Alan J Gow; Ross D Henderson; Susana Munoz-Maniega; Catherine Murray; Natalie A Royle; Emma Sprooten; Maria C Valdés Hernández; Mark E Bastin; Lars Penke; John M Starr; Joanna M Wardlaw; Ian J Deary

doi:10.1037/hea0000012

Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Tom Booth^*, Rene Mõttus, Janie Corley, Alan J Gow, Ross D Henderson, Susana Munoz-Maniega, Catherine Murray, Natalie A Royle, Emma Sprooten, Maria C Valdés Hernández, Mark E Bastin, Lars Penke, John M Starr, Joanna M Wardlaw, Ian J Deary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure, a 5-factor public-domain personality measure (http://ipip.ori.org), and underwent a structural magnetic resonance brain scan at the mean age of 73 years, yielding 3 measures of whole brain integrity: average white matter fractional anisotropy (FA), brain-tissue loss, and white matter hyperintensities (N = 529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain-tissue loss (β = -0.11, p

Original language	English
Pages (from-to)	1477-1486
Number of pages	10
Journal	Health Psychology
Volume	33
Issue number	12
Early online date	18 Nov 2013
DOIs	https://doi.org/10.1037/hea0000012
Publication status	Published - Dec 2014

Keywords / Materials (for Non-textual outputs)

five-factor model
brain volume
white matter hyperintensities
fractional anisotropy
health behaviors
BODY-MASS INDEX
WHITE-MATTER INTEGRITY
6-YEAR FOLLOW-UP
ALZHEIMERS-DISEASE
PHYSICAL-ACTIVITY
OLDER-ADULTS
AGE
TRAITS
SAMPLE
VOLUME

Access to Document

10.1037/hea0000012

Booth Mottus 1936 - Health Psychology
© Personality, Health, and Brain Integrity : The Lothian Birth Cohort Study 1936. / Booth, Tom; Mõttus, Rene; Corley, Janie; Gow, Alan J; Henderson, Ross D; Munoz-Maniega, Susana; Murray, Catherine; Royle, Natalie A; Sprooten, Emma; Hernández, Maria C Valdés; Bastin, Mark E; Penke, Lars; Starr, John M; Wardlaw, Joanna M; Deary, Ian J. In: Health Psychology, 2013. Research output: Contribution to journal › Article
Accepted author manuscript, 1.47 MB

http://psycnet.apa.org/index.cfm?fa=search.displayrecord&uid=2013-39890-001

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
8/06/11 → 7/03/15
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J. (Principal Investigator)
UK-based charities
1/01/11 → 31/03/16
Project: Research

Cite this

Booth, T., Mõttus, R., Corley, J., Gow, A. J., Henderson, R. D., Munoz-Maniega, S., Murray, C., Royle, N. A., Sprooten, E., Hernández, M. C. V., Bastin, M. E., Penke, L., Starr, J. M., Wardlaw, J. M., & Deary, I. J. (2014). Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936. Health Psychology, 33(12), 1477-1486. https://doi.org/10.1037/hea0000012

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title = "Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936",

abstract = "Objective: To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure, a 5-factor public-domain personality measure (http://ipip.ori.org), and underwent a structural magnetic resonance brain scan at the mean age of 73 years, yielding 3 measures of whole brain integrity: average white matter fractional anisotropy (FA), brain-tissue loss, and white matter hyperintensities (N = 529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviors on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain-tissue loss (β = -0.11, p ",

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author = "Tom Booth and Rene M{\~o}ttus and Janie Corley and Gow, \{Alan J\} and Henderson, \{Ross D\} and Susana Munoz-Maniega and Catherine Murray and Royle, \{Natalie A\} and Emma Sprooten and Hern{\'a}ndez, \{Maria C Vald{\'e}s\} and Bastin, \{Mark E\} and Lars Penke and Starr, \{John M\} and Wardlaw, \{Joanna M\} and Deary, \{Ian J\}",

year = "2014",

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language = "English",

volume = "33",

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AU - Henderson, Ross D

AU - Munoz-Maniega, Susana

AU - Murray, Catherine

AU - Royle, Natalie A

AU - Sprooten, Emma

AU - Hernández, Maria C Valdés

AU - Bastin, Mark E

AU - Penke, Lars

AU - Starr, John M

AU - Wardlaw, Joanna M

AU - Deary, Ian J

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Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Disconnected Mind [Phase 2]

Cite this