pH sensing in living cells using fluorescent microspheres

Mark Bradley, Lois Alexander, Karen Duncan, Mourad Chennaoui, Anita C. Jones, Rosario M. Sanchez-Martin

Research output: Contribution to journalArticlepeer-review


Intracellular pH in living cells is measured in real time at the single cell level using fluorescently covalently loaded microspheres as efficient carrier systems and stable sensors. The use of these sensors immobilized covalently onto polymeric particles allows analysis of intracellular pH flux over long period of time and eliminates the disadvantages such as dilution within the cell, elimination via leakage or compartmentalization. (C) 2007 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 1 Jan 2008




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