TY - JOUR
T1 - Pharmaceuticals from transgenic livestock
AU - Clark, A. J.
AU - Simons, P.
AU - Wilmut, I.
AU - Lathe, R.
PY - 1987
Y1 - 1987
N2 - By combining regulatory elements derived from one gene with the coding sequence from another, it is now possible to direct the synthesis of a particular protein to a specific body tissue in a recombinant or 'transgenic' animal. This paper discusses the possibility that transgenic methodology may be applied to the production of human therapeutic proteins in farm animals. We review the feasibility of generating transgenic livestock, explore the possibility of harvesting human proteins, in quantity, from the milk of transgenic dairy animals, and examine the theoretical, technical and financial aspects of the approach.
AB - By combining regulatory elements derived from one gene with the coding sequence from another, it is now possible to direct the synthesis of a particular protein to a specific body tissue in a recombinant or 'transgenic' animal. This paper discusses the possibility that transgenic methodology may be applied to the production of human therapeutic proteins in farm animals. We review the feasibility of generating transgenic livestock, explore the possibility of harvesting human proteins, in quantity, from the milk of transgenic dairy animals, and examine the theoretical, technical and financial aspects of the approach.
UR - http://www.scopus.com/inward/record.url?scp=0023122154&partnerID=8YFLogxK
U2 - 10.1016/0167-7799(87)90076-X
DO - 10.1016/0167-7799(87)90076-X
M3 - Review article
AN - SCOPUS:0023122154
SN - 0167-7799
VL - 5
SP - 20
EP - 24
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 1
ER -