Projects per year
Trypanosomatid parasites cause diseases in humans and livestock. It was reported that partial inhibition of the vacuolar ATPase (V-ATPase) affects dependence of Trypanosoma brucei on its mitochondrial genome (kDNA), a target of the anti-trypanosomatid drug isometamidium. Here we report that V-ATPase inhibition with bafilomycin A1 (BafA) provides partial resistance to genetic knockdown of mitochondrial gene expression. BafA does not promote long-term survival after kDNA loss, but in its presence, isometamidium causes less damage to kDNA.
|Number of pages||7|
|Journal||Antimicrobial Agents and Chemotherapy|
|Early online date||18 Jun 2018|
|Publication status||Published - 27 Aug 2018|
- RNA editing
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- 1 Finished
Mitochondrial biogenesis and function in trypanosomes
1/04/14 → 30/06/21
- School of Biological Sciences - Personal Chair of Parasite and Mitochondrial Biology
Person: Academic: Research Active