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Trypanosomatid parasites cause diseases in humans and livestock. It was reported that partial inhibition of the vacuolar ATPase (V-ATPase) affects dependence of Trypanosoma brucei on its mitochondrial genome (kDNA), a target of the anti-trypanosomatid drug isometamidium. Here we report that V-ATPase inhibition with bafilomycin A1 (BafA) provides partial resistance to genetic knockdown of mitochondrial gene expression. BafA does not promote long-term survival after kDNA loss, but in its presence, isometamidium causes less damage to kDNA.
- RNA editing
FingerprintDive into the research topics of 'Pharmacological Inhibition of the Vacuolar ATPase in Bloodstream-Form <i>Trypanosoma brucei</i> Rescues Genetic Knockdown of Mitochondrial Gene Expression'. Together they form a unique fingerprint.
- 1 Finished
1/04/14 → 30/06/21