Phenotype of bovine mononuclear phagocytes- An update

S C Talker; Jayne Hope; A Summerfield

doi:10.1016/j.vetimm.2024.110836

Phenotype of bovine mononuclear phagocytes- An update

S C Talker, Jayne Hope, A Summerfield

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic similarities and the high plasticity of monocytic cells. Despite these challenges, significant progress has been made in cattle research through multicolor flow cytometry, transcriptomics of sorted subsets, and single-cell RNA-sequencing. Here, we provide an overview of established and proposed phenotypic classifications in the bovine mononuclear phagocyte system and discuss the challenges of marker discovery.

Original language	English
Article number	110836
Pages (from-to)	1-16
Number of pages	16
Journal	Veterinary Immunology and Immunopathology
Volume	277
Early online date	24 Sept 2024
DOIs	https://doi.org/10.1016/j.vetimm.2024.110836
Publication status	Published - Nov 2024

Keywords / Materials (for Non-textual outputs)

Animals
Biomarkers
Cattle/immunology
Flow Cytometry/veterinary
Monocytes/immunology
Mononuclear Phagocyte System/immunology
Phagocytes/immunology
Phenotype

Access to Document

10.1016/j.vetimm.2024.110836

BovDCMon_finalAccepted author manuscript, 294 KBLicence: CC BY-NC-ND

1 Finished
1 Active

ISP 2 2023/28 Prevention & Control of Infectious Diseases
Wilson, A.
1/04/23 → 31/03/28
Project: Research
VACCINE: Defining signature responses at the innate-adaptive interface to inform the design of vaccines inducing cellular immunity
Bell, C., Freeman, T., Hope, J. & Morrison, I.
BBSRC
1/02/17 → 31/01/22
Project: Research

Cite this

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title = "Phenotype of bovine mononuclear phagocytes- An update",

abstract = "Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic similarities and the high plasticity of monocytic cells. Despite these challenges, significant progress has been made in cattle research through multicolor flow cytometry, transcriptomics of sorted subsets, and single-cell RNA-sequencing. Here, we provide an overview of established and proposed phenotypic classifications in the bovine mononuclear phagocyte system and discuss the challenges of marker discovery.",

keywords = "Animals, Biomarkers, Cattle/immunology, Flow Cytometry/veterinary, Monocytes/immunology, Mononuclear Phagocyte System/immunology, Phagocytes/immunology, Phenotype",

author = "Talker, {S C} and Jayne Hope and A Summerfield",

year = "2024",

month = nov,

doi = "10.1016/j.vetimm.2024.110836",

language = "English",

volume = "277",

pages = "1--16",

journal = "Veterinary Immunology and Immunopathology",

issn = "0165-2427",

publisher = "Elsevier",

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TY - JOUR

T1 - Phenotype of bovine mononuclear phagocytes- An update

AU - Talker, S C

AU - Hope, Jayne

AU - Summerfield, A

PY - 2024/11

Y1 - 2024/11

N2 - Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic similarities and the high plasticity of monocytic cells. Despite these challenges, significant progress has been made in cattle research through multicolor flow cytometry, transcriptomics of sorted subsets, and single-cell RNA-sequencing. Here, we provide an overview of established and proposed phenotypic classifications in the bovine mononuclear phagocyte system and discuss the challenges of marker discovery.

AB - Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic similarities and the high plasticity of monocytic cells. Despite these challenges, significant progress has been made in cattle research through multicolor flow cytometry, transcriptomics of sorted subsets, and single-cell RNA-sequencing. Here, we provide an overview of established and proposed phenotypic classifications in the bovine mononuclear phagocyte system and discuss the challenges of marker discovery.

KW - Animals

KW - Biomarkers

KW - Cattle/immunology

KW - Flow Cytometry/veterinary

KW - Monocytes/immunology

KW - Mononuclear Phagocyte System/immunology

KW - Phagocytes/immunology

KW - Phenotype

U2 - 10.1016/j.vetimm.2024.110836

DO - 10.1016/j.vetimm.2024.110836

M3 - Review article

C2 - 39368394

SN - 0165-2427

VL - 277

SP - 1

EP - 16

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

M1 - 110836

ER -

Phenotype of bovine mononuclear phagocytes- An update

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

ISP 2 2023/28 Prevention & Control of Infectious Diseases

VACCINE: Defining signature responses at the innate-adaptive interface to inform the design of vaccines inducing cellular immunity

Cite this