TY - JOUR
T1 - Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus
AU - Busche, A.
AU - Angulo, A.
AU - Kay-Jackson, P.
AU - Ghazal, P.
AU - Messerle, M.
PY - 2008/6
Y1 - 2008/6
N2 - Immediate-early (IE) genes are the Wrst genes
to be transcribed during the lytic replication cycle of
cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the
pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed
mouse CMV mutants with disruptions in the major IE
genes, ie1 and ie3, to study the roles of these genes in the
context of the viral infection. Here we summarize the current results on the characterization of these mutants and
give a perspective of the future research in this Weld.
AB - Immediate-early (IE) genes are the Wrst genes
to be transcribed during the lytic replication cycle of
cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the
pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed
mouse CMV mutants with disruptions in the major IE
genes, ie1 and ie3, to study the roles of these genes in the
context of the viral infection. Here we summarize the current results on the characterization of these mutants and
give a perspective of the future research in this Weld.
KW - Mouse cytomegalovirus
KW - Immediate-early genes
KW - Viral mutants
KW - Phenotypes
UR - http://www.scopus.com/inward/record.url?scp=42249086779&partnerID=8YFLogxK
U2 - 10.1007/s00430-008-0076-3
DO - 10.1007/s00430-008-0076-3
M3 - Article
VL - 197
SP - 233
EP - 240
JO - Medical Microbiology and Immunology
JF - Medical Microbiology and Immunology
SN - 0300-8584
IS - 2
ER -