Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus

A. Busche, A. Angulo, P. Kay-Jackson, P. Ghazal, M. Messerle

Research output: Contribution to journalArticlepeer-review

Abstract

Immediate-early (IE) genes are the Wrst genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection. Here we summarize the current results on the characterization of these mutants and give a perspective of the future research in this Weld.
Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalMedical Microbiology and Immunology
Volume197
Issue number2
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Mouse cytomegalovirus
  • Immediate-early genes
  • Viral mutants
  • Phenotypes

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