Phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents

J S McLean, M C Frame, R I Freshney, P F Vaughan, A E Mackie, I Singer

Research output: Contribution to journalArticlepeer-review

Abstract

Glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. The effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. Glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity GABA uptake). Cytostasis was also seen at high cell densities in non-small cell lung carcinoma with a concomitant reduction in plasminogen activator activity and endothelial mitogenesis. Preliminary data on surfactant production in A549 cells suggests that the repression of malignancy-associated properties is accompanied by an increase in cell differentiation. Treatment of the WIL adenocarcinoma gown as a xenograft in nude mice caused total cessation of growth and massive central necrosis in the tumor.
Original languageEnglish
Pages (from-to)1101-6
Number of pages6
JournalAnticancer research
Volume6
Issue number5
Publication statusPublished - 1986

Keywords

  • Astrocytoma
  • Brain Chemistry
  • Carcinoma, Non-Small-Cell Lung
  • Cell Line
  • Chorionic Gonadotropin
  • Dactinomycin
  • Dexamethasone
  • Glioma
  • Glucocorticoids
  • Glutamate-Ammonia Ligase
  • Humans
  • Lung Neoplasms
  • Mitosis
  • Phenotype
  • Plasminogen Activators
  • Tissue Extracts
  • gamma-Aminobutyric Acid

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