PIK3CA-related overgrowth: silver bullets from the cancer arsenal?

Ralitsa R. Madsen, Robert K. Semple

Research output: Contribution to journalComment/debatepeer-review

Abstract / Description of output

Mutations activating growth factor signaling often drive cancer growth. Many also arise in isolation, causing developmental growth disorders. PIK3CA, encoding a catalytic subunit of phosphoinositide 3-kinase, is a cardinal example of this paradigm. Here recent progress in cancer drug repurposing for PIK3CA-driven overgrowth is discussed.
Original languageEnglish
JournalTrends in Molecular Medicine
Publication statusPublished - 8 Mar 2022


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