TY - JOUR
T1 - Pipe Phantoms with Applications in Molecular Imaging and System Characterization
AU - Wang, Shiying
AU - Herbst, Elizabeth B
AU - Pye, Stephen D
AU - Moran, Carmel M
AU - Hossack, John A
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Pipe (vessel) phantoms mimicking human tissue and blood flow are widely used for cardiovascular related research in medical ultrasound. Pipe phantom studies require the development of materials and liquids that match the acoustic properties of soft tissue, blood vessel wall, and blood. Over recent years, pipe phantoms have been developed to mimic the molecular properties of the simulated blood vessels. In this paper, the design, construction, and functionalization of pipe phantoms are introduced and validated for applications in molecular imaging and ultrasound imaging system characterization. There are three major types of pipe phantoms introduced: a gelatin-based pipe phantom, a polydimethylsiloxane (PDMS)-based pipe phantom, and the "Edinburgh Pipe Phantom" (EPP). These phantoms may be used in the validation and assessment of the dynamics of microbubble-based contrast agents and, in the case of a small diameter tube phantom (EPP), for assessing imaging system spatial resolution/contrast performance. The materials and procedures required to address each of the phantoms are described.
AB - Pipe (vessel) phantoms mimicking human tissue and blood flow are widely used for cardiovascular related research in medical ultrasound. Pipe phantom studies require the development of materials and liquids that match the acoustic properties of soft tissue, blood vessel wall, and blood. Over recent years, pipe phantoms have been developed to mimic the molecular properties of the simulated blood vessels. In this paper, the design, construction, and functionalization of pipe phantoms are introduced and validated for applications in molecular imaging and ultrasound imaging system characterization. There are three major types of pipe phantoms introduced: a gelatin-based pipe phantom, a polydimethylsiloxane (PDMS)-based pipe phantom, and the "Edinburgh Pipe Phantom" (EPP). These phantoms may be used in the validation and assessment of the dynamics of microbubble-based contrast agents and, in the case of a small diameter tube phantom (EPP), for assessing imaging system spatial resolution/contrast performance. The materials and procedures required to address each of the phantoms are described.
U2 - 10.1109/TUFFC.2016.2626465
DO - 10.1109/TUFFC.2016.2626465
M3 - Article
C2 - 27845659
SN - 0885-3010
VL - 64
JO - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
IS - 1
ER -