Pipe Phantoms with Applications in Molecular Imaging and System Characterization

Shiying Wang, Elizabeth B Herbst, Stephen D Pye, Carmel M Moran, John A Hossack

Research output: Contribution to journalArticlepeer-review

Abstract

Pipe (vessel) phantoms mimicking human tissue and blood flow are widely used for cardiovascular related research in medical ultrasound. Pipe phantom studies require the development of materials and liquids that match the acoustic properties of soft tissue, blood vessel wall, and blood. Over recent years, pipe phantoms have been developed to mimic the molecular properties of the simulated blood vessels. In this paper, the design, construction, and functionalization of pipe phantoms are introduced and validated for applications in molecular imaging and ultrasound imaging system characterization. There are three major types of pipe phantoms introduced: a gelatin-based pipe phantom, a polydimethylsiloxane (PDMS)-based pipe phantom, and the "Edinburgh Pipe Phantom" (EPP). These phantoms may be used in the validation and assessment of the dynamics of microbubble-based contrast agents and, in the case of a small diameter tube phantom (EPP), for assessing imaging system spatial resolution/contrast performance. The materials and procedures required to address each of the phantoms are described.

Original languageEnglish
JournalIEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
Volume64
Issue number1
Early online date9 Nov 2016
DOIs
Publication statusPublished - 1 Jan 2017

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