Pituitary macroadenoma leading to hypogonadism in a dog

Camilla Johnsen, Glynn Woods, Yi Lin Tan , Tobias Schwarz, Laura Blackwood, Richard Mellanby, Silke Salavati

Research output: Contribution to journalArticlepeer-review


A six-year-old male entire dachshund presented for investigation of decreased testicular size noted over the last six months and progressive lethargy for two months. Apart from small symmetrical testicles and a small prostate gland, physical examination revealed no abnormalities. Neurological examination was repeatably normal. Extensive diagnostic investigations for extracranial disease with a focus on reproductive and metabolic-endocrine disorders revealed no abnormalities. Decreased testosterone (0.2 nmol/l) with inappropriately low luteinising hormone (<0.7 iu/l) and follicle stimulating hormone (2.1 ng/ml) in comparison with six other male entire dogs was detected. Based on the exclusion of all other conditions, intracranial disease was suspected. MRI of the head revealed a 2 x 1.8 x 1.5 cm mass arising from the pituitary fossa. Radiotherapy (12 fractions of 4 Gy, three days per week for four weeks, three-dimensional conformal plan, 6 MV) and pain relief resulted in resolution of lethargy. Twelve months after initial diagnosis, the dog was asymptomatic, while the testicles remained small.
Original languageEnglish
Journal Vet Record Case Reports
Publication statusPublished - 12 Nov 2020


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