Placebo-controlled comparison of candoxatril, an orally active neutral endopeptidase inhibitor, and captopril in patients with chronic heart failure

D B Northridge, P F Currie, D E Newby, J J McMurray, M Ford, N A Boon, H J Dargie

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: To compare the effects on exercise capacity of the neutral endopeptidase inhibitor candoxatril, and the angiotensin converting enzyme inhibitor captopril, in patients with mild to moderate heart failure.

METHODS: In this multi-centre double-blind placebo controlled study, 60 patients with NYHA Class I-III heart failure were randomised to candoxatril 200 mg b.d. (n = 22), captopril 25-50 mg b.d. (n = 23) or placebo (n = 15). Treadmill exercise tests were carried out weekly during a 5-week single-blind placebo run-in phase until a stable baseline was achieved, and repeated at 4 weekly intervals during the 12-week double-blind treatment phase.

RESULTS: Nine patients withdrew from the study--four candoxatril and five captopril. The placebo-adjusted increase in exercise duration after 12 weeks was 56 s (95% CI, -26 to +137 s; P = 0.12) with candoxatril and 37 s (-43 to + 117 s; P = 0.29) with captopril.

CONCLUSIONS: Both candoxatril and captopril were well tolerated and treadmill exercise duration appeared to increase during 12 weeks of therapy but this did not achieve statistical significance. This study tentatively suggests that in patients with heart failure, neutral endopeptidase inhibition may provide similar symptomatic benefits to angiotensin converting enzyme inhibition.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalEuropean Journal of Heart Failure
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 1999

Keywords

  • Angiotensin-Converting Enzyme Inhibitors
  • Captopril
  • Double-Blind Method
  • Exercise Test
  • Exercise Tolerance
  • Female
  • Heart Failure
  • Humans
  • Indans
  • Male
  • Middle Aged
  • Propionates
  • Protease Inhibitors

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