Placental efficiency and adaptation: endocrine regulation

A. L. Fowden; A. N. Sferruzzi-Perri; P. M. Coan; M. Constancia; G. J. Burton

doi:10.1113/jphysiol.2009.173013

Placental efficiency and adaptation: endocrine regulation

A. L. Fowden^*, A. N. Sferruzzi-Perri, P. M. Coan, M. Constancia, G. J. Burton

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

Original language	English
Pages (from-to)	3459-3472
Number of pages	14
Journal	The Journal of Physiology
Volume	587
Issue number	14
DOIs	https://doi.org/10.1113/jphysiol.2009.173013
Publication status	Published - 15 Jul 2009

Keywords / Materials (for Non-textual outputs)

GROWTH-FACTOR-I
AMINO-ACID-TRANSPORT
DIFFUSIONAL EXCHANGE CHARACTERISTICS
LEPTIN RECEPTOR EXPRESSION
MATERNAL-FETAL EXCHANGE
INTRAUTERINE GROWTH
LATE-GESTATION
NUTRIENT TRANSPORT
GUINEA-PIG
BIRTH-WEIGHT

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10.1113/jphysiol.2009.173013

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title = "Placental efficiency and adaptation: endocrine regulation",

abstract = "Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.",

keywords = "GROWTH-FACTOR-I, AMINO-ACID-TRANSPORT, DIFFUSIONAL EXCHANGE CHARACTERISTICS, LEPTIN RECEPTOR EXPRESSION, MATERNAL-FETAL EXCHANGE, INTRAUTERINE GROWTH, LATE-GESTATION, NUTRIENT TRANSPORT, GUINEA-PIG, BIRTH-WEIGHT",

author = "Fowden, {A. L.} and Sferruzzi-Perri, {A. N.} and Coan, {P. M.} and M. Constancia and Burton, {G. J.}",

year = "2009",

month = jul,

day = "15",

doi = "10.1113/jphysiol.2009.173013",

language = "English",

volume = "587",

pages = "3459--3472",

journal = "The Journal of Physiology",

issn = "0022-3751",

publisher = "Wiley",

number = "14",

}

TY - JOUR

T1 - Placental efficiency and adaptation

T2 - endocrine regulation

AU - Fowden, A. L.

AU - Sferruzzi-Perri, A. N.

AU - Coan, P. M.

AU - Constancia, M.

AU - Burton, G. J.

PY - 2009/7/15

Y1 - 2009/7/15

N2 - Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

AB - Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

KW - GROWTH-FACTOR-I

KW - AMINO-ACID-TRANSPORT

KW - DIFFUSIONAL EXCHANGE CHARACTERISTICS

KW - LEPTIN RECEPTOR EXPRESSION

KW - MATERNAL-FETAL EXCHANGE

KW - INTRAUTERINE GROWTH

KW - LATE-GESTATION

KW - NUTRIENT TRANSPORT

KW - GUINEA-PIG

KW - BIRTH-WEIGHT

U2 - 10.1113/jphysiol.2009.173013

DO - 10.1113/jphysiol.2009.173013

M3 - Literature review

SN - 0022-3751

VL - 587

SP - 3459

EP - 3472

JO - The Journal of Physiology

JF - The Journal of Physiology

IS - 14

ER -

Placental efficiency and adaptation: endocrine regulation

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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