Placental efficiency and adaptation: endocrine regulation

A. L. Fowden*, A. N. Sferruzzi-Perri, P. M. Coan, M. Constancia, G. J. Burton

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a passive recipient of nutrients from the placenta. It exerts a significant acquisitive drive for nutrients, which acts through morphological and functional adaptations in the placenta, particularly when the genetically determined drive for fetal growth is compromised by adverse intrauterine conditions. These adaptations alter the efficiency with which the placenta supports fetal growth, which results in optimal growth for prevailing conditions in utero. This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes.

Original languageEnglish
Pages (from-to)3459-3472
Number of pages14
JournalJournal of Physiology
Volume587
Issue number14
DOIs
Publication statusPublished - 15 Jul 2009

Keywords

  • GROWTH-FACTOR-I
  • AMINO-ACID-TRANSPORT
  • DIFFUSIONAL EXCHANGE CHARACTERISTICS
  • LEPTIN RECEPTOR EXPRESSION
  • MATERNAL-FETAL EXCHANGE
  • INTRAUTERINE GROWTH
  • LATE-GESTATION
  • NUTRIENT TRANSPORT
  • GUINEA-PIG
  • BIRTH-WEIGHT

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